2,2-Dimethylpropylphosphonoylcyclohexane | 1246895-40-8

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: 2,2-Dimethylpropylphosphonoylcyclohexane
• 英文别名: 2,2-dimethylpropylphosphonoylcyclohexane
• CAS: 1246895-40-8
• 化学式: C₁₁H₂₃OP
• 分子量: 202.277
• InChiKey: ULQBQHJNANYHEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  特戊醛 、 环已基膦 在 三氟乙酸 作用下， 以97%的产率得到2,2-Dimethylpropylphosphonoylcyclohexane
  参考文献：
  名称：

  Single-Step Synthesis of Secondary Phosphine Oxides

  摘要：

  We report that in the presence of trifluoroacetic acid primary phosphines undergo efficient addition to aldehydes to form the corresponding secondary phosphine oxides in 47-97% yield. This transformation is compatible with aryl and alkyl phosphines, as well as a broad range of aldehydes, including formaldehyde. By using 1,5-dialdehydes as reaction partners, the addition provides a straightforward route to bis(phosphine oxides), which are difficult to prepare by alternative methods. In the presence of boron trifluoride diethyl etherate as reagent, benzophenone was shown to couple to phenylphosphine and cyclohexylphosphine in 92% and 72% yield, respectively. Twenty-three examples are presented.

  DOI：

  10.1021/om100571w

文献信息

• Single-Step Synthesis of Secondary Phosphine Oxides
  作者：Aaron J. Bloomfield、Jack M. Qian、Seth B. Herzon

  DOI：10.1021/om100571w

  日期：2010.9.27

  We report that in the presence of trifluoroacetic acid primary phosphines undergo efficient addition to aldehydes to form the corresponding secondary phosphine oxides in 47-97% yield. This transformation is compatible with aryl and alkyl phosphines, as well as a broad range of aldehydes, including formaldehyde. By using 1,5-dialdehydes as reaction partners, the addition provides a straightforward route to bis(phosphine oxides), which are difficult to prepare by alternative methods. In the presence of boron trifluoride diethyl etherate as reagent, benzophenone was shown to couple to phenylphosphine and cyclohexylphosphine in 92% and 72% yield, respectively. Twenty-three examples are presented.