4-[2-(3′,4′-dimethoxy-biphenyl-4-yl)-[1,3]dioxolan-2-yl]-pyridine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[2-(3′,4′-dimethoxy-biphenyl-4-yl)-[1,3]dioxolan-2-yl]-pyridine
• 英文别名: 4-[2-[4-(3,4-Dimethoxyphenyl)phenyl]-1,3-dioxolan-2-yl]pyridine；4-[2-[4-(3,4-dimethoxyphenyl)phenyl]-1,3-dioxolan-2-yl]pyridine
• 化学式: C₂₂H₂₁NO₄
• 分子量: 363.413
• InChiKey: GBRLNBNJUPWHSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NOVEL CYTOCHROME P450 INHIBITORS AND THEIR METHOD OF USE
  申请人：CORTENDO AB (PUBL)

  公开号：US20150210641A1

  公开（公告）日：2015-07-30

  Embodiments of the present invention relate to novel cytochrome P450 inhibitors and pharmaceutical compositions thereof having a disease-modifying action in the treatment of diseases associated with the overproduction of cortisol that include metabolic syndrome, and any involving the overproduction of cortisol.

  本发明实施例涉及一种新型细胞色素P450抑制剂及其药物组合物，具有改变疾病作用，用于治疗与皮质醇过度产生相关的疾病，包括代谢综合征和任何涉及皮质醇过度产生的疾病。
• [EN] NOVEL CYTOCHROME P450 INHIBITORS AND THEIR METHOD OF USE<br/>[FR] NOUVEAUX INHIBITEURS DU CYTOCHROME P450 ET LEUR MÉTHODE D'UTILISATION
  申请人：CORTENDO AB PUBL

  公开号：WO2015112369A1

  公开（公告）日：2015-07-30

  Embodiments of the present invention relate to novel cytochrome P450 inhibitors and pharmaceutical compositions thereof having a disease-modifying action in the treatment of diseases associated with the overproduction of Cortisol that include metabolic syndrome, and any involving the overproduction of Cortisol.