4-Apeba

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Apeba
• 英文别名: 2-(4-azaniumylphenoxy)ethyl-[2-(4-bromophenyl)ethyl]-dimethylazanium;dibromide
• 化学式: C18H25Br3N2O
• 分子量: 525.1
• InChiKey: MICAQOBHYBUDOG-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.97
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  36.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• IN-VITRO DIAGNOSIS OF HISTAMINE INTOLERANCE SYNDROME
  申请人：Immundiagnostik AG

  公开号：EP4103946A1

  公开（公告）日：2022-12-21
• [EN] IN-VITRO DIAGNOSIS OF HISTAMINE INTOLERANCE SYNDROME<br/>[FR] DIAGNOSTIC IN VITRO DU SYNDROME D'INTOLÉRANCE À L'HISTAMINE
  申请人：IMMUNDIAGNOSTIK AG

  公开号：WO2021160696A1

  公开（公告）日：2021-08-19

  A method of diagnosis of histamine intolerance in a person suspected of suffering from histamine intolerance syndrome. Isotope-labeled histamine metabolites, namely imidazole acetic acid and methylimidazole acetic acid are identified and measured in serum, plasma, urine and other bodily fluids following derivatization with a hydrazinoquinoline derivatization agent using the LC-MS/MS technique. The method and analytical technique is very sensitive and allows a safe use of an isotope-labeled oral histamine load as well as time-dependent measurements of the total activity of secreted and membrane-associated DAO enzymes for the sake of a differential diagnosis of histamine intolerance syndrome compared to food allergy, food hypersensitivity or food intolerance.