1-(2-Methylpiperidin-1-yl)-2-(4-methyl-5-pyridin-3-yl-4H-[1,2,4]triazol-3-yl-sulfanyl)ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(2-Methylpiperidin-1-yl)-2-(4-methyl-5-pyridin-3-yl-4H-[1,2,4]triazol-3-yl-sulfanyl)ethanone
• 英文别名: 1-(2-methylpiperidin-1-yl)-2-[(4-methyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]ethanone
• 化学式: C₁₆H₂₁N₅OS
• 分子量: 331.4
• InChiKey: DEGYKTPCWTZDNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  89.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS<br/>[FR] PETITES MOLÉCULES DE PROTECTION DE WASP, COMPOSITIONS, PROCÉDÉS ET UTILISATIONS DE CELLES-CI DANS LE TRAITEMENT DE TROUBLES OU D'ÉTATS LIÉS À L'IMMUNITÉ INNÉE ET ACQUISE
  申请人：UNIV BAR ILAN

  公开号：WO2018055627A1

  公开（公告）日：2018-03-29

  The present invention provides specific small molecule compounds that modulate degradation and stability of Wiskott-Aldrich Syndrome protein (WASp), methods and uses thereof in innate and acquired immune-related disorders or conditions, specifically, in primary and secondary immune-deficiencies.