[4-[4-(Thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]methanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-[4-(Thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]methanamine
• 英文别名: [4-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]methanamine
• 化学式: C₁₆H₁₇NO₃S₂
• 分子量: 335.4
• InChiKey: GRRDUDJQILRRES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS<br/>[FR] INHIBITEURS SÉLECTIFS DE MÉTALLOPROTÉINASES MATRICIELLES
  申请人：UNIV NOTRE DAME DU LAC

  公开号：WO2015127302A1

  公开（公告）日：2015-08-27

  The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.

  本发明提供了用于治疗受基质金属蛋白酶（MMPs）调节的疾病、疾病或病情的化合物、组合物和方法。这些化合物可以是选择性MMP抑制剂，例如MMP-2、MMP-9和/或MMP-14的选择性抑制剂。该疾病、疾病或病情可以包括中风、神经系统疾病、眼科疾病或创伤，例如慢性创伤或糖尿病性创伤。
• [EN] ACCELERATION OF DIABETIC WOUND HEALING<br/>[FR] ACCÉLÉRATION DE LA CICATRISATION DES PLAIES DIABÉTIQUES
  申请人：UNIV NOTRE DAME DU LAC

  公开号：WO2016044844A1

  公开（公告）日：2016-03-24

  The invention provides compounds, compositions, and methods to improve or accelerate the healing of a wound. In various embodiments, the methods can include the topical treatment of the wound with the enzyme MMP-8, or the topical treatment of the wound with MMP-8 in combination with administration of an MMP-9 inhibitor, to accelerate the healing of the wound.

  本发明提供了化合物、组成物和方法，以改善或加速伤口的愈合。在各种实施例中，该方法可以包括使用酶MMP-8局部治疗伤口，或者使用MMP-8与MMP-9抑制剂的联合局部治疗伤口，以加速伤口的愈合。
• Selective matrix metalloproteinase inhibitors
  申请人：University of Notre Dame du Lac

  公开号：US10253013B2

  公开（公告）日：2019-04-09

  The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.

  本发明提供了用于治疗受基质金属蛋白酶（MMPs）调节的疾病、失调或病症的化合物、组合物和方法。这些化合物可以是选择性 MMP 抑制剂，例如，MMP-2、MMP-9 和/或 MMP-14 的选择性抑制剂。疾病、失调或病症可包括中风、神经失调、眼科失调或伤口，如慢性伤口或糖尿病伤口等。
• Acceleration of diabetic wound healing
  申请人：University of Notre Dame du Lac

  公开号：US10357546B2

  公开（公告）日：2019-07-23

  The invention provides compounds, compositions, and methods to improve or accelerate the healing of a wound. In various embodiments, the methods can include the topical treatment of the wound with the enzyme MMP-8, or the topical treatment of the wound with MMP-8 in combination with administration of an MMP-9 inhibitor, to accelerate the healing of the wound.

  本发明提供了改善或加速伤口愈合的化合物、组合物和方法。在各种实施方案中，这些方法可包括用 MMP-8 酶局部治疗伤口，或用 MMP-8 结合 MMP-9 抑制剂局部治疗伤口，以加速伤口愈合。
• SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS
  申请人：University of Notre Dame du Lac

  公开号：US20170015647A1

  公开（公告）日：2017-01-19

  The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.