flucarbazone-sodium

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: flucarbazone-sodium
• 英文别名: 4,5-dihydro-3-methoxy-4-methyl-5-oxo-N-((2-(trifluoromethoxy)phenyl)sulfonyl)-1H-1,2,4-triazole-1-carboxamide sodium salt；flucarbazone-Na；sodium;3-methoxy-4-methyl-5-oxo-N-[2-(trifluoromethoxy)phenyl]sulfonyl-1,2,4-triazole-1-carboximidate
• 化学式: C₁₂H₁₀F₃N₄O₆S*Na
• 分子量: 418.286
• InChiKey: UOUXAYAIONPXDH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.78
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  11

ADMET

代谢

通过两条途径代谢。一条途径涉及磺胺乳酸盐的氧化脱羧形成磺胺乙酸盐。另一条途径涉及磺胺乳酸盐和磺胺乙酸盐的水解，生成磺胺。/来自表格/

Metabolized via two pathways. One pathway involved the oxidative decarboxylation of sulfonamide lactate to form sulfonamide acetate. The other pathway involved the hydrolysis of sulfonamide lactate and sulfonamide acetate to give sulfonamide. /From table/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、球囊阀面罩设备或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果患者呕吐，让患者向前倾或将其置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗救助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预防癫痫发作，如有必要，进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于无意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。考虑使用药物治疗肺水肿……。对于严重的支气管痉挛，考虑给予β激动剂，如沙丁胺醇……。监测心率和必要时治疗心律失常……。开始静脉输注D5W /SRP: "保持开放"，最低流量/。如果出现低血容量的迹象，使用0.9%生理盐水（NS）或乳酸林格氏液。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象……。使用地西泮或劳拉西泮治疗癫痫……。使用丙美卡因氢氯化物协助眼部冲洗……。 /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室动物：急性暴露/大鼠：非皮肤致敏物/埃弗里斯特技术/

/LABORATORY ANIMALS: Acute Exposure/ Rat: Not a /dermal/ sensitizer /Everest technical/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室动物：急性暴露/皮肤致敏-豚鼠：非致敏剂/最终用途产品：珠峰

/LABORATORY ANIMALS: Acute Exposure/ Dermal Sensitization-Guinea Pig: Not a sensitizer /End-Use product: Everest/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在吸收、分布、代谢或排泄方面没有性别差异。基于尿液排泄，吸收率为15-30%，血浆中最高浓度在30分钟内达到。在宰杀时，组织和胴体中的放射性物质含量不到1%。组织中残留最高的是肝脏。在24小时内，超过90%的给药剂量被消除。尿液和粪便中的主要成分是未改变的母体，占总给药剂量的90-95%。

There were no sex-related differences in the absorption, distribution, metabolism or excretion. Based on urinary excretion, absorption was 15-30% and maximum plasma concentrations were achieved within 30 minutes. At sacrifice, tissues and carcass contained less than 1% of radioactivity. The highest residue in the tissues was in the liver. Greater than 90% of the administered dose was eliminated within 24 hours. The major component in urine and feces was unchanged parent which represented 90-95% of the administered dose. /From table/

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为产物：
  描述：

  3-methoxy-4-methyl-1-phenoxycarbonyl-4,5-dihydro-1H-1,2,4-triazol-5-one 、 2-(三氟甲氧基)苯磺酰胺 在 4-甲基-2-戊酮 、 sodium hydroxide 作用下， 以 水 为溶剂， 以90%的产率得到flucarbazone-sodium
  参考文献：
  名称：

  一种氟唑磺隆的合成方法

  摘要：

  本发明涉及一种氟唑磺隆的合成方法，该合成方法以5‑甲氧基‑4‑甲基‑1,2,4‑三唑‑5‑酮为原料，在催化剂4‑二甲胺基吡啶和溶剂水的作用下，反应生成5‑甲氧基‑4‑甲基‑2‑苯氧羰基‑2,4‑二氢‑3H‑1,2,4‑三唑‑3‑酮；然后5‑甲氧基‑4‑甲基‑2‑苯氧炭基‑2,4‑二氢‑3H‑1,2,4‑三唑‑3‑酮与甲基异丁酮和三氟甲氧基苯磺酰胺反应生成氟唑磺隆。本发明的优点在于：本发明在合成5‑甲氧基‑4‑甲基‑2‑苯氧羰基‑2,4‑二氢‑3H‑1,2,4‑三唑‑3‑酮时，采用4‑二甲胺基吡啶为催化剂，4‑二甲胺基吡啶为高效酰化剂，可使化合物中的叔醇基团直接酯化,得到高产率、高纯度的酯化产物；同时，采用水作为反应溶剂，水成本较低，降低制备成本，且水作为溶剂，污染小。

  公开号：

  CN106478533A

文献信息

• HERBICIDAL COMPOSITIONS
  申请人：Bayer Aktiengesellschaft

  公开号：US20220053762A1

  公开（公告）日：2022-02-24

  The present invention provides compositions comprising herbicidally active compounds (A) and (B), where (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)], and (B) represents one or more herbicides [component (B)]. The application further relates to a method and to the use of the herbicidal composition according to the invention for controlling harmful plants or for regulating growth.

  本发明提供了包含除草活性化合物（A）和（B）的组合物，其中（A）代表通式（I）的一个或多个化合物或其农药兼容盐[组分（A）]，（B）代表一个或多个除草剂[组分（B）]。该申请进一步涉及一种方法和利用本发明的除草组合物来控制有害植物或调节生长。
• [EN] NEW CRYSTAL FORM OF FLUCARBAZONE-SODIUM<br/>[FR] NOUVELLE FORME CRISTALLINE DE FLUCARBAZONE-SODIUM
  申请人：JIANGSU ROTAM CHEMISTRY CO LTD

  公开号：WO2021134242A1

  公开（公告）日：2021-07-08

  A new crystal form of flucarbazone-sodium, a preparation method thereof and the use thereof in controlling the growth of undesired plants.

  一种氟吡唑酮钠的新晶体形态，其制备方法以及在控制不良植物生长方面的应用。
• Phenyl substituted heterocyclic compounds useful as herbicides
  申请人：Friedmann Alberto Adrian

  公开号：US20050090399A1

  公开（公告）日：2005-04-28

  Compounds of formula (I) wherein the substituents are as defined in claim 1, and also agronomically acceptable salts, isomers and enantiomers of such compounds are suitable for use as herbicides.

  式(I)化合物中的取代基如权利要求1所定义，以及这种化合物的农业上可接受的盐、异构体和对映体，适用于作为除草剂使用。
• USE OF ALS INHIBITOR HERBICIDES FOR CONTROL OF UNWANTED VEGETATION IN ALS INHIBITOR HERBICIDE TOLERANT BETA VULGARIS PLANTS
  申请人：BAYER CROPSCIENCE AG

  公开号：US20150313237A1

  公开（公告）日：2015-11-05

  The present invention relates to the use of the ALS inhibitor herbicides for controlling unwanted vegetation in ALS inhibitor herbicide tolerant Beta vulgaris plants, more especially, present invention relates to the use of ALS inhibitor herbicides for control of unwanted vegetation in Beta vulgaris , preferably in sugar beet growing areas in which the Beta vulgaris , preferably sugar beet comprise mutations in the ALS gene where the tryptophan at position 569 in the encoded ALS enzyme is substituted by another amino acid (preferably by leucine), and a mutation in the ALS gene where the proline at position 188 in the encoded ALS enzyme is substituted by another amino acid (preferably by serine).

  本发明涉及使用ALS抑制剂除草剂来控制ALS抑制剂除草剂耐受的Beta vulgaris植物中的不良杂草，特别是涉及使用ALS抑制剂除草剂来控制Beta vulgaris中的不良杂草，更好地说，在Beta vulgaris，特别是在甜菜种植区域，其中Beta vulgaris，特别是糖用甜菜包括ALS基因突变，编码的ALS酶中的位于位置569的色氨酸被其他氨基酸（优选为亮氨酸）替换，并且编码的ALS酶中的位于位置188的脯氨酸被其他氨基酸（优选为丝氨酸）替换。
• METHOD OF PREVENTING CONSOLIDATION OF AGRICULTURAL CHEMICAL ACTIVE INGREDIENT
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP1382245A1

  公开（公告）日：2004-01-21

  An agricultural chemical active ingredient which is solid at room temperature, may cake into a large lump during storage or transportation after the production, and if it is pulverized after the production or stored for a longer period of time, it is more likely to cake. If such an agricultural chemical active ingredient is put in a drum container, it will cake and will be difficult to take out from the container. Accordingly, it may be packaged in small portions and put in a container, or after being taken out from the container, the lump is crushed by a hammer. Thus, before it is mixed with various agricultural adjuvants and subjected to a pulverization step, its handing is troublesome. By adding a small amount of an inorganic substance composed mainly of silica to a powder of an agricultural chemical active ingredient which is solid at room temperature, caking of the agricultural chemical active ingredient can be prevented, and handling such as formulation, transportation or storage, of the agricultural chemical, can be facilitated.

  农业化学活性成分在室温下为固体，在生产后的储存或运输过程中可能会结成大块，如果在生产后将其粉碎或储存较长时间，则更容易结块。如果将这种农用化学活性成分放在桶装容器中，就会结块，而且很难从容器中取出。因此，可以将其分成小块包装并放入容器中，或者在从容器中取出后，用锤子将块状物敲碎。因此，在将其与各种农用佐剂混合并进行粉碎步骤之前，处理起来很麻烦。 通过向室温下为固体的农用化学活性成分粉末中添加少量主要由二氧化硅组成的无机物，可以防止农用化学活性成分结块，便于农用化学品的配制、运输或储存等操作。