dimethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate | 1373709-99-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: dimethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
• 英文别名: Dimethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
• CAS: 1373709-99-9
• 化学式: C₁₇H₁₇NO₅
• 分子量: 315.326
• InChiKey: VTODPEVUQTUEMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  85.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-(3-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester 在 graphite oxide 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以92%的产率得到dimethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
  参考文献：
  名称：

  Graphite oxide mediated oxidative aromatization of 1,4-dihydropyridines into pyridine derivatives

  摘要：

  A new approach utilizing graphite oxide as an oxidizing agent is applied for the oxidative aromatization of 1,4-dihydropyridines. Graphite oxide efficiently aromatized Hantzsch 1,4-dihydropyridines into their corresponding pyridine derivatives in excellent yields. The reaction was carried out in toluene at 100 degrees C. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.03.026

文献信息

• Graphite oxide mediated oxidative aromatization of 1,4-dihydropyridines into pyridine derivatives
  作者：Maryam Mirza-Aghayan、Rabah Boukherroub、Mohammad Nemati、Mahshid Rahimifard

  DOI：10.1016/j.tetlet.2012.03.026

  日期：2012.5

  A new approach utilizing graphite oxide as an oxidizing agent is applied for the oxidative aromatization of 1,4-dihydropyridines. Graphite oxide efficiently aromatized Hantzsch 1,4-dihydropyridines into their corresponding pyridine derivatives in excellent yields. The reaction was carried out in toluene at 100 degrees C. (C) 2012 Elsevier Ltd. All rights reserved.