1-(2,5-Dimethoxy-phenyl)-3-propyl-thiourea | 147751-48-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,5-Dimethoxy-phenyl)-3-propyl-thiourea
• 英文别名: 1-(2,5-Dimethoxyphenyl)-3-propyl-2-thiourea；1-(2,5-dimethoxyphenyl)-3-propylthiourea
• CAS: 147751-48-2
• 化学式: C₁₂H₁₈N₂O₂S
• mdl: MFCD00030073
• 分子量: 254.353
• InChiKey: CIHQGCMTNXGTCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  正丙胺 、 2,5-二甲氧基异硫氰酸苯酯 以 二氯甲烷 为溶剂， 生成 1-(2,5-Dimethoxy-phenyl)-3-propyl-thiourea
  参考文献：
  名称：

  Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents

  摘要：

  A series of 1-alkyl-3-phenylthiourea analogues were prepared and evaluated as HDL- and Apo A-I-elevating and triglyceride-lowering agents. Several derivatives were superior to gemfibrozil (1). The optimal analogue 8d (HDL376) was shown to raise HDL cholesterol in the rat, hamster, dog, and monkey models. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.034

文献信息

• Two-component initiator system (amine-free) with very good storage stability and particular suitability for acid systems
  申请人：Utterodt Andreas

  公开号：US20070040151A1

  公开（公告）日：2007-02-22

  A two-component initiator system having accelerators for curing polymerizable materials comprising the following components: (a) a hydroperoxide compound containing one or more hydroperoxide groups that are bound to a tertiary carbon; (b) a thiourea derivative; and (c) as accelerator, a copper compound which is soluble in the preparation is preferably free of amine and is particularly suited for polymerizable dental compositions.
• Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents
  作者：Gary M. Coppola、Robert E. Damon、J. Bruce Eskesen、Dennis S. France、James R. Paterniti

  DOI：10.1016/j.bmcl.2005.09.034

  日期：2006.1

  A series of 1-alkyl-3-phenylthiourea analogues were prepared and evaluated as HDL- and Apo A-I-elevating and triglyceride-lowering agents. Several derivatives were superior to gemfibrozil (1). The optimal analogue 8d (HDL376) was shown to raise HDL cholesterol in the rat, hamster, dog, and monkey models. (c) 2005 Elsevier Ltd. All rights reserved.