2-Carboxyoxybenzoic acid | 855178-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Carboxyoxybenzoic acid
• CAS: 855178-01-7
• 化学式: C₈H₆O₅
• 分子量: 182.133
• InChiKey: CLTAZWADHDXZQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Carboxyoxybenzoic acid 在 硫酸 、 肼 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Synthesis, antiproliferative activity, and molecular docking studies of curcumin analogues bearing pyrazole ring

  摘要：

  Several curcumin analogues bearing pyrazole were synthesized and characterized by IR, NMR, and mass spectral data. There were four tested compounds among 11 synthesized compounds, which were evaluated for antiproliferative activity and showed significant activity in both one-dose and five-dose assays. The antiproliferative effects were tested on a panel of 60 cell lines, according to the National Cancer Institute screening protocol. The most active compounds among the series were 3,5-bis(4-hydroxy-3-methylstyryl)-1H-pyrazole-1-carboxamide (3k) which showed mean percent growth inhibition of 116.09 in one-dose assay at 10 A mu M, and GI(50) values were ranging between 0.0912 and 2.36 A mu M in five-dose assay. The best results were recorded on the leukaemia cell lines with value ranging from 0.0912 to 0.365 A mu M. All the tested compounds showed broad-spectrum antiproliferative activity over different cancer cell lines. When compared with the standard drug paclitaxel, the compound 3k showed superior activity on nearly 42 cell lines. The molecular docking study was performed to explore the binding interaction of these curcumin analogues with the active site of EGFR tyrosine kinase (EGFR-TK). The hydroxyl group of both phenyl rings was important for the rein-geminated hydrogen bonding by either side chain or backbone with the active site of EGFR-TK.Four curcumin analogues were evaluated for their antiproliferative activity and showed promising results. The molecular docking studies showed that all the compounds (3a-k) were well accommodated in the EGFR tyrosine kinase.[GRAPHICS].

  DOI：

  10.1007/s00044-015-1457-y

文献信息

• Stable soluble 1,2-diamino-cyclohexane platinum complexes
  申请人：ANDRULIS RESEARCH CORPORATION

  公开号：EP0228298A2

  公开（公告）日：1987-07-08

  Platinum complexes of the formula wherein Z is -CO- or a single bond and R is -COOH or -SO3H, and the pharmaceutically acceptable salts thereof with bases, are stable readily water-soluble pharmaceutically active compounds having antitumor, anti-inflammatory and trypanocidal activities.

  式中 Z 为-CO-或单键，R 为-COOH 或-SO3H 的铂配合物及其与碱的药学上可接受的盐是稳定的易溶于水的药用活性化合物，具有抗肿瘤、消炎和杀锥虫活性。
• Method for preparing block polyphenylene ether-polycarbonates
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0417511A2

  公开（公告）日：1991-03-20

  Block polyphenylene ether-polycarbonate copolymers are prepared by the reaction of a salicylate-terminated polycarbonate with a polyphenylene ether in the presence of a polycarbonate-forming transesterification catalyst. The reaction may be conducted in solution or in the melt, typically at temperatures in the range of about 100-300°C. The preferred catalysts are tetraarylborates, especially tetraalkylammonium tetraarylborates.

  嵌段聚苯醚-聚碳酸酯共聚物是通过水杨酸封端聚碳酸酯与聚苯醚在形成聚碳酸酯的酯交换催化剂存在下发生反应而制备的。反应可在溶液或熔体中进行，通常温度在 100-300°C 之间。首选催化剂是四芳基硼酸盐，特别是四烷基铵四芳基硼酸盐。
• Method for preparing reactively terminated polycarbonates
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0417514A2

  公开（公告）日：1991-03-20

  Salicylate-terminated polycarbonates are prepared by the reaction of an organic dihydroxy compound and phosgene in the presence of a salicylate chloroformate, preferably o-­carbomethoxyphenyl chloroformate. The reaction is typically conducted interfacially. The salicylate chloroformate may be produced in situ by the reaction of phosgene with a mixture of a salicylic acid ester and a bisphenol such as bisphenol A.

  水杨酸封端聚碳酸酯是通过有机二羟基化合物和光气在水杨酸氯甲酸酯（最好是邻甲氧基苯基氯甲酸酯）存在下发生反应制备的。反应通常在界面上进行。水杨酸氯甲酸酯可通过光气与水杨酸酯和双酚（如双酚 A）混合物的反应就地生成。
• Production of high BN alkaline earth metal single-aromatic ring hydrocarbyl salicylate-carboxylate
  申请人：Chevron Chemical S.A.

  公开号：EP0985726A1

  公开（公告）日：2000-03-15

  An overbased alkaline earth metal single-aromatic ring hydrocarbyl salicylatecarboxylate is produced by overbasing a mixture of a single-aromatic ring hydrocarbyl salicylate, at least one solvent, a metal hydroxide, and an alkyl polyhydric alcohol alkaline earth metal hydroxide, by contacting that mixture with carbon dioxide under overbasing reaction conditions. The alkyl group of the alkyl polyhydric alcohol has from one to five carbon atoms. The overbased metal single-aromatic ring hydrocarbyl salicylate is treated, before, during, or subsequent to overbasing, with a long-chain carboxylic acid to form a single-aromatic ring hydrocarbyl salicylate-carboxylate.

  碱土金属单芳香环烃基水杨酸羧酸酯的过碱法是将单芳香环烃基水杨酸酯、至少一种溶剂、一种金属氢氧化物和碱土金属氢氧化物烷基多元醇的混合物在过碱反应条件下与二氧化碳接触而制得的。烷基多元醇的烷基具有 1 至 5 个碳原子。在过基反应之前、期间或之后，用长链羧酸处理过基金属单芳香环烃基水杨酸酯，以形成单芳香环烃基水杨酸酯-羧酸盐。
• An additive composition having low temperature viscosity, corrosion and detergent properties
  申请人：Chevron Oronite S.A.

  公开号：EP1632551A2

  公开（公告）日：2006-03-08

  An additive composition providing improved low temperature viscosity, corrosion and detergent properties when used in lubricating oils for internal combustion engines is presented. The additive composition comprises an unsulfurized carboxylate detergent-dispersant additive having been modified by incorporation of from about 3.2 wt % to 7.5 wt %, based on the total additive composition, of an alkaline earth metal salt of a linear, saturated carboxylic acid having from about 16 to about 20 carbon atoms and wherein the additive composition has a superalkalinization ratio of less than about 1.4:1, a TBN of less than about 200 and a sediment value of less than about 0.2 % by volume.

  本文介绍了一种添加剂组合物，该组合物用于内燃机润滑油时，可改善低温粘度、腐蚀和清净特性。该添加剂组合物包括一种未硫化的羧酸盐清净分散剂添加剂，该添加剂通过加入约 3.2 重量 % 至 7.5 重量 % 的碱土金属盐（基于添加剂组合物总量）进行改性，该碱土金属盐是一种具有约 16 至 20 个碳原子的线性饱和羧酸，其中该添加剂组合物的超碱化比小于约 1.4:1，TBN 小于约 200，沉积值小于约 0.2%（体积百分比）。