3-(2-chlorophenyl)-5-methyl-N-(2-methylpropyl)-1,2-oxazole-4-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-chlorophenyl)-5-methyl-N-(2-methylpropyl)-1,2-oxazole-4-carboxamide
• 化学式: C₁₅H₁₇ClN₂O₂
• mdl: MFCD01182882
• 分子量: 292.76
• InChiKey: MPMCEOGASOEVHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] POLY(VINYL ALCOHOL) NANOCARRIERS<br/>[FR] NANOVECTEURS À BASE D'ALCOOL (POLY)VINYLIQUE
  申请人：UNIV CALIFORNIA

  公开号：WO2017031084A1

  公开（公告）日：2017-02-23

  The present invention provides a nanoparticle including at least one poly(vinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties selected from: a therapeutic agent having a boronic acid moiety, wherein the therapeutic agent is covalently linked to the PVA via a boronate ester bond; a crosslinking group having a disulfide moiety, wherein the crosslinking group is covalently linked to the PVA, and a porphyrin, wherein the porphyrin is covalently linked to the PVA. Use of the nanoparticles for tumor detection and the treatment of diseases, including methods for photodynamic therapy and photothermal therapy, are also described.