NF023 | 99777-90-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: NF023
• 英文别名: 8,8’-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulfonic acid, hexasodium salt；3-[[C-hydroxy-N-[3-[C-hydroxy-N-(4,6,8-trisulfonaphthalen-1-yl)carbonimidoyl]phenyl]carbonimidoyl]amino]-N-(4,6,8-trisulfonaphthalen-1-yl)benzenecarboximidic acid
• CAS: 99777-90-9
• 化学式: C₃₅H₂₆N₄O₂₁S₆
• 分子量: 1031.0
• InChiKey: JMONOAYAUIIKMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  66
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  476
• 氢给体数：
  10
• 氢受体数：
  21

反应信息

• 作为产物：
  描述：

  1-萘胺-4,6,8-三磺酸 在 sodium carbonate 、 iron(II) chloride 作用下， 生成 NF023
  参考文献：
  名称：

  Balaban; King, Journal of the Chemical Society, 1927, p. 3091

  摘要：

  DOI：

文献信息

• AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS
  申请人：LICHTER Jay

  公开号：US20090306225A1

  公开（公告）日：2009-12-10

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文公开了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过将免疫调节剂和/或耳压调节剂组合物和配方直接应用于耳媒介和/或耳内靶区，或通过灌注进入耳媒介和/或耳内结构，局部给患有耳部疾病的个体进行治疗。
• Auris Formulations for Treating Otic Diseases and Conditions
  申请人：Otonomy, Inc.

  公开号：US20160228357A1

  公开（公告）日：2016-08-11

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文介绍了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过直接将免疫调节剂和/或耳压调节剂组合物和配方局部应用于患有耳部疾病的个体的耳媒体和/或耳内靶区，或通过灌注到耳媒体和/或耳内结构中。
• COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE AND DEMYELINATING DISEASES
  申请人：UNIVERSIDAD DEL PAIS VASCO-EUSKAL HERRIKO UNIBERSITATEA

  公开号：EP1655032A1

  公开（公告）日：2006-05-10

  The present invention is related to the treatment of demyelinating and autoimmune diseases, more particularly with the treatment of multiple sclerosis. The treatment consists of the administration of P2X purinergic receptors antagonist substances which cause a remission of the symptoms common to these types of diseases. This is demonstrated in in vitro cell models as well as in animal models.

  本发明涉及脱髓鞘疾病和自身免疫性疾病的治疗，尤其是多发性硬化症的治疗。治疗方法包括施用 P2X 嘌呤能受体拮抗剂物质，这些物质可使这些类型疾病的常见症状得到缓解。体外细胞模型和动物模型都证明了这一点。
• COMPONENT AND METHOD FOR TREATING VIRAL DISEASE
  申请人：Institut Pasteur of Shanghai, Chinese Academy of Sciences

  公开号：EP2875829A1

  公开（公告）日：2015-05-27

  The present invention relates to compositions and methods for treating viral diseases. Disclosed for the first time, a new use of P2X receptor antagonists for the preparation of a composition for treating viral infections. The P2X receptor antagonists achieve preventive or therapeutic effect on hand foot and mouth disease by inhibiting viruses.

  本发明涉及治疗病毒性疾病的组合物和方法。首次公开了 P2X 受体拮抗剂用于制备治疗病毒感染的组合物的新用途。P2X 受体拮抗剂通过抑制病毒达到预防或治疗手足口病的效果。
• Auris formulations for treating otic diseases and conditions
  申请人：Otonomy, Inc.

  公开号：US10272034B2

  公开（公告）日：2019-04-30

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文公开了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过将免疫调节剂和/或免疫调节压力调节剂组合物和制剂直接施用到耳道介质和/或耳道间质目标区域，或通过灌注到耳道介质和/或耳道间质结构中，对耳道疾病患者进行局部给药。