N-(1-Azabicyclo[2.2.2]oct-3-yl)(4-bromobenzamide) | 355386-81-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-Azabicyclo[2.2.2]oct-3-yl)(4-bromobenzamide)
• 英文别名: N-(1-azabicyclo[2.2.2]octan-3-yl)-4-bromobenzamide
• CAS: 355386-81-1
• 化学式: C₁₄H₁₇BrN₂O
• mdl: MFCD05796142
• 分子量: 309.206
• InChiKey: BXVSCDNQMVRJHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compounds
  申请人：——

  公开号：US20030008867A1

  公开（公告）日：2003-01-09

  Compounds of formula I: 1 wherein A, D, Ar 1 , E and Ar 2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

  式I化合物： 1 其中A、D、Ar 1 、E和Ar 2 如说明书中所定义，它们的制备方法，含有它们的药物组合物，以及它们在治疗中的应用，特别是在精神病和智力障碍疾病的治疗或预防中的应用。
• New Compounds
  申请人：Phillips Eifion

  公开号：US20070149563A1

  公开（公告）日：2007-06-28

  Compounds of formula I: wherein A, D, Ar 1 , E and Ar 2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

  化合物I的公式：其中A、D、Ar1、E和Ar2的定义如规范中所述，制备它们的过程，含有它们的制药组合物以及它们在治疗中的使用，特别是在治疗或预防精神病和智力障碍方面的应用。
• NOVEL BIARYLCARBOXAMIDES
  申请人：AstraZeneca AB

  公开号：EP1259508A1

  公开（公告）日：2002-11-27
• Imaging agents and methods of imaging alpha7-nicotinic cholinergic receptor
  申请人：Pomper Martin G.

  公开号：US20100034741A1

  公开（公告）日：2010-02-11

  The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the α7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express α7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.
• US7001914B2
  申请人：——

  公开号：US7001914B2

  公开（公告）日：2006-02-21