4-Ethyl-1-methyl-2-methylsulfanylbenzene

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-Ethyl-1-methyl-2-methylsulfanylbenzene
• 英文别名: 4-ethyl-1-methyl-2-methylsulfanylbenzene
• 化学式: C₁₀H₁₄S
• 分子量: 166.29
• InChiKey: UCZZBQMMJUBSIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] ANTIMICROBIALS AND METHODS OF MAKING AND USING SAME<br/>[FR] ANTIMICROBIENS ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：MELINTA THERAPEUTICS INC

  公开号：WO2017193023A1

  公开（公告）日：2017-11-09

  The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I): or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.

  本公开涉及抗微生物化合物领域以及制备和使用这些化合物的方法。这些化合物对于治疗、预防、减少人类和动物微生物感染的风险以及延缓微生物感染的发生都是有用的。在某些实施例中，本公开提供一种化合物的化学式(I)：或其互变异构体或该化合物或互变异构体的药用可接受盐。
• A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES
  申请人：The Scripps Research Institute

  公开号：EP3656781A1

  公开（公告）日：2020-05-27

  Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.

  本文提供的是非天然核苷酸类似物，它们主要带有疏水性核碱基，在 DNA 聚合酶介导的 DNA 复制或 RNA 聚合酶介导的 RNA 转录过程中形成非天然碱基对。通过这种方式，非天然核碱基可以以特定位点的方式引入寡核苷酸（单链或双链 DNA 或 RNA）中，从而实现特定位点的裂解，或者提供一种活性连接体，这种连接体可以通过与伯氨基反应或通过与非天然核碱基连接体的炔基发生点击化学反应，与载货试剂发生官能化反应。
• Charge-bearing cyclodextrin polymeric materials and methods of making and using same
  申请人：CycloPure, Inc.

  公开号：US11155646B2

  公开（公告）日：2021-10-26

  The present disclosure relates to charge-bearing polymeric materials and methods of their use for purifying fluid samples from micropollutants, such as anionic micropollutants.

  本公开涉及带电聚合物材料及其用于净化流体样品中的微污染物（如阴离子微污染物）的方法。
• CHARGE-BEARING CYCLODEXTRIN POLYMERIC MATERIALS AND METHODS OF MAKING AND USING SAME
  申请人：CycloPure, Inc.

  公开号：US20210163631A1

  公开（公告）日：2021-06-03

  The present disclosure relates to charge-bearing polymeric materials and methods of their use for purifying fluid samples from micropollutants, such as anionic micropollutants.