2-[[4-[3-(1,3-Benzothiazol-2-yl)-2-(4-carboxy-2-methoxyphenyl)-1,3-dihydrotetrazol-3-ium-5-yl]benzoyl]amino]ethanesulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[[4-[3-(1,3-Benzothiazol-2-yl)-2-(4-carboxy-2-methoxyphenyl)-1,3-dihydrotetrazol-3-ium-5-yl]benzoyl]amino]ethanesulfonate
• 英文别名: 2-[[4-[3-(1,3-benzothiazol-2-yl)-2-(4-carboxy-2-methoxyphenyl)-1,3-dihydrotetrazol-3-ium-5-yl]benzoyl]amino]ethanesulfonate
• 化学式: C25H22N6O7S2
• 分子量: 582.6
• InChiKey: QZHPOWUOLXLXGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  214
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• 2-SUBSTITUTED BENZOTHIAZOLYL-3-SUBSTITUTED PHENYL-5-SUBSTITUTED SULFONATED PHENYL-2H-TETRAZOLIUM SALT, REAGENT FOR BIOLOGICAL COMPONENT CONCENTRATION MEASUREMENT CONTAINING SAID SALT, AND BIOLOGICAL COMPONENT CONCENTRATION MEASUREMENT METHOD USING SAID SALT
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：US20190185465A1

  公开（公告）日：2019-06-20

  A 2-substituted benzothiazolyl-3-substituted phenyl-5-substituted sulfonated phenyl-2H-tetrazolium salt represented by the following Formula (1): wherein, R 1 can be a hydrogen atom, a hydroxyl group, a methoxy group, and an ethoxy group; R 2 can be a nitro group, —OR 4 , and a carboxyl group; R 3 is a hydrogen atom, a methyl group, or an ethyl group, while at least one is a methyl group or an ethyl group; R 4 is a methyl group or an ethyl group; m is 1 or 2; n is an integer from 0 to 2; p is 0 or 1; n+p is 1 or greater; q is 1 or 2; when q is 2, the OR 3 's are disposed adjacently to each other and may form a ring; and X is a hydrogen atom or an alkali metal atom.

  以下是由式（1）表示的2-取代苯并噻唑基-3-取代苯基-5-取代磺酸苯基-2H-四唑盐： 其中，R1可以是氢原子、羟基、甲氧基和乙氧基；R2可以是硝基、—OR4和羧基；R3是氢原子、甲基或乙基，至少一个是甲基或乙基；R4是甲基或乙基；m为1或2；n是0到2的整数；p为0或1；n+p≥1；q为1或2；当q为2时，OR3相邻排列并且可以形成环；X为氢原子或碱金属原子。
• Method of colorimetry and reagent for use therein
  申请人：——

  公开号：US20040142406A1

  公开（公告）日：2004-07-22

  The present invention provides a calorimetric method that can perform a simple and reliable analysis in a short time. The method includes transferring an electron from an analyte to a coloring reagent that produces color by reduction via a mediator by using an oxidoreductase; and performing qualitative or quantitative analysis of the analyte by measuring color produced in the coloring reagent. The enzyme reaction of this method is a single stage reaction, and the color production reaction occurs via the mediator. Therefore, the measurement can be performed in a short time. Since this reaction requires neither hydrogen peroxide nor oxygen, the measured values are highly reliable.

  本发明提供了一种热量计法，可以在短时间内进行简单可靠的分析。该方法包括使用氧化还原酶将电子从待分析物转移至染色试剂，通过介质还原产生颜色，并通过测量染色试剂中产生的颜色进行待分析物的定性或定量分析。该方法的酶反应是单阶段反应，颜色产生反应通过介质进行。因此，可在短时间内进行测量。由于该反应既不需要过氧化氢也不需要氧气，因此测量结果非常可靠。
• METHOD OF DETERMINING BILE ACID CONJUGATED WITH SULFURIC ACID AND KIT THEREFOR
  申请人：MARUKIN SHOYU CO., LTD.

  公开号：EP0811692A1

  公开（公告）日：1997-12-10

  The present invention provides a method of assaying sulfate-conjugated bile acid using bile acid sulfate sulfatase and a reductive system indicator which comprises using an 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium salt as the reductive system indicator as well as a kit therefor. In accordance with the invention, assaying of sulfate-conjugated bile acid can be performed in a single reaction system using an automated analyzer generally used for clinical examinations, with markedly improved assay operability. The assay is possible using an automated analyzer without requiring much labor. The assay treatment performance of samples can be improved as well.

  本发明提供了一种使用胆汁酸硫酸盐硫酸酯酶和还原体系指示剂检测硫酸盐结合胆汁酸的方法，该方法包括使用 2-(4-碘苯基)-3-(4-硝基苯基)-5-(2,4-二磺酸苯基)-2H-四唑鎓盐作为还原体系指示剂以及相关试剂盒。根据本发明，硫酸盐结合胆汁酸的测定可在单个反应系统中进行，使用的自动分析仪一般用于临床检查，测定的可操作性明显提高。使用自动分析仪进行化验无需大量人力。样品的化验处理性能也能得到改善。
• Stabilized tetrazolium-phenazine reagent compositions and methods for using the same
  申请人：Lifescan, Inc.

  公开号：EP1312921A1

  公开（公告）日：2003-05-21

  Stabilized tetrazolium dye-phenazine reagent compositions and methods for their use in the measurement of an analyte in a sample are provided. The subject reagent compositions include: (1) a tetrazolium dye component, e.g., a water soluble tetrazolium salt; (2) a phenazine component; and (3) an effective amount of one or more tetrazolium dye-phenazine stabilizing reagents, e.g., an inorganic Group IIIA compound and/or a flavin. In many embodiments, the subject reagent compositions include additional members of an analyte oxidizing signal producing system, such as: an analyte oxidizing enzyme, e.g., an analyte dehydrogenase or an analyte oxidase; and an enzyme cofactor. Also provided are test strips that include the subject reagent compositions, as well as systems and kits incorporating the subject test strips. The subject reagent compositions, test strips, systems and kits find use in the detection of a wide variety of analytes in a sample, such as a physiological sample, e.g., blood or a fraction thereof, or ISF (interstitial fluid).

  本发明提供了稳定四氮唑染料-吩嗪试剂组合物及其用于测量样品中分析物的方法。试剂组合物包括(1)四唑鎓染料成分，例如水溶性四唑鎓盐；(2)酚嗪成分；和(3)有效量的一种或多种四唑鎓染料-酚嗪稳定试剂，例如无机 IIIA 族化合物和/或黄素。在许多实施方案中，所述试剂组合物包括分析物氧化信号产生系统的其他成员，例如：分析物氧化酶，如分析物脱氢酶或分析物氧化酶；以及酶辅助因子。此外，还提供了包括主题试剂组合物的试纸，以及包含主题试纸的系统和试剂盒。这些试剂组合物、试纸条、系统和试剂盒可用于检测样品中的各种分析物，如生理样品，如血液或其一部分，或间质液（ISF）。
• METHOD OF COLORIMETRY AND REAGENT FOR USE THEREIN
  申请人：ARKRAY, Inc.

  公开号：EP1457572A1

  公开（公告）日：2004-09-15

  The present invention provides a colorimetric method that can perform a simple and reliable analysis in a short time. The method includes transferring an electron from an analyte to a coloring reagent that produces color by reduction via a mediator by using an oxidoreductase; and performing qualitative or quantitative analysis of the analyte by measuring color produced in the coloring reagent. The enzyme reaction of this method is a single stage reaction, and the color production reaction occurs via the mediator. Therefore, the measurement can be performed in a short time. Since this reaction requires neither hydrogen peroxide nor oxygen, the measured values are highly reliable.

  本发明提供了一种比色法，可在短时间内进行简单可靠的分析。该方法包括利用氧化还原酶将电子从被分析物转移到通过介质还原产生颜色的显色试剂中；以及通过测量显色试剂中产生的颜色对被分析物进行定性或定量分析。该方法中的酶反应是一个单级反应，而颜色生成反应是通过介质发生的。因此，测量可在短时间内完成。由于该反应既不需要过氧化氢，也不需要氧气，因此测量值非常可靠。