3-(7-methoxy-2-(4-methoxy-2-methylphenyl)benzofuran-5-yl)propane-1-ol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 3-(7-methoxy-2-(4-methoxy-2-methylphenyl)benzofuran-5-yl)propane-1-ol
• 英文别名: 3-[7-Methoxy-2-(4-methoxy-2-methylphenyl)-1-benzofuran-5-yl]propan-1-ol；3-[7-methoxy-2-(4-methoxy-2-methylphenyl)-1-benzofuran-5-yl]propan-1-ol
• 化学式: C₂₀H₂₂O₄
• 分子量: 326.392
• InChiKey: FNYZIYIKZJWFQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL 2-PHENYLBENZOFURAN DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASE COMPRISING SAME AS ACTIVE INGREDIENT
  申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

  公开号：US20160332980A1

  公开（公告）日：2016-11-17

  The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.

  本发明涉及一种新的2-苯基苯并呋喃衍生物或其药学上可接受的盐，以及其制备方法，以及包含其作为活性成分的用于预防或治疗炎症性疾病的药物组合物，根据本发明的新的2-苯基苯并呋喃衍生物或其药学上可接受的盐在抑制由巨噬细胞诱导的NO、IL-6和TNF-alpha方面具有显著的有效性，因此可以有利地用于预防或治疗炎症性疾病的药物组合物中。
• 2-phenylbenzofuran derivatives, method for preparing the same and use of the same for treating inflammatory disease
  申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

  公开号：US10053443B2

  公开（公告）日：2018-08-21

  The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.

  本发明涉及一种新型 2-苯基苯并呋喃衍生物或其药学上可接受的盐、其生产方法以及一种用于预防或治疗炎症性疾病的药物组合物，其中包含该衍生物或其药学上可接受的盐作为活性成分，根据本发明的新型 2-苯基苯并呋喃衍生物或其药学上可接受的盐在抑制巨噬细胞诱导的 NO、IL-6 和 TNF-α 方面效果显著，因此可有利地用于预防或治疗炎症性疾病的药物组合物中。