(4-benzyl-piperidine-1-yl)-(1-phenyl-3-thiophen-2-yl-1H-pyrazol-4-yl)-methanone | 6551-86-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (4-benzyl-piperidine-1-yl)-(1-phenyl-3-thiophen-2-yl-1H-pyrazol-4-yl)-methanone
• 英文别名: (4-Benzylpiperidin-1-yl)-(1-phenyl-3-thiophen-2-ylpyrazol-4-yl)methanone
• CAS: 6551-86-6
• 化学式: C₂₆H₂₅N₃OS
• 分子量: 427.57
• InChiKey: YQAMECSUDVXDTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] MODULATION OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ACTIVITY<br/>[FR] MODULATION DE L'ACTIVITE DES RECEPTEURS ACTIVES PAR LES PROLIFERATEURS DE PEROXYSOMES
  申请人：CAREX SA

  公开号：WO2004037248A2

  公开（公告）日：2004-05-06

  The present invention relates to compounds, compositions and methods useful for modulating nuclear receptors activity in cells, and for treating and/or preventing various diseases and conditions mediated by said nuclear receptors, including metabolic or cell proliferative disorders. According to particular aspects, the present invention relates to compounds, compositions and methods useful for modulating activities of the Peroxisome Proliferator Activated Receptors (PPARs) and for treating and/or preventing various diseases and conditions mediated by said nuclear receptors. More specifically, it relates to Peroxisome Proliferator Activated Receptor-gamma (PPAR-gamma) ligands, which are useful in the modulation of blood glucose levels and in the increase of insulin sensitivity in patients in need thereof. The properties of the compounds and compositions of the invention make these PPAR ligands particularly useful in the treatment of those diseases and conditions including diabetes, atherosclerosis, hyperglycemia, dyslipidemia, obesity, syndrome X, insulin resistance, hypertension, neuropathy, microvascular diseases (e.g. retinopathy, nephropathy), macrovascular diseases (e.g. myocardial infarction, stroke, heart failure) in mammals.