N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride
• 英文别名: 4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]-N-(4-pyrrolidin-1-ylpiperidin-1-yl)benzamide;hydrochloride
• 化学式: C28H31ClN6OS
• 分子量: 535.1
• InChiKey: JJNFJYOLILPVPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.73
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Methods and compositions for treating pancreatitis
  申请人：BAYLOR RESEARCH INSTITUTE

  公开号：US10758551B2

  公开（公告）日：2020-09-01

  It was discovered that NF-κB signaling pathway plays a central role in pancreatitis, and inhibition of NF-κB signaling has the potential to reduce the incidence of pancreatitis and protect pancreatic tissues from inflammatory damage. Aspects of the disclosure relate to a method for inhibiting or treating pancreatitis in a subject in need thereof comprising administering a therapeutically effective amount of an NF-κB signaling pathway inhibitor to the subject.

  研究发现，NF-κB 信号通路在胰腺炎中起着核心作用，抑制 NF-κB 信号通路有可能降低胰腺炎的发病率并保护胰腺组织免受炎症损伤。本公开的各个方面涉及一种抑制或治疗有需要的受试者的胰腺炎的方法，该方法包括向受试者施用治疗有效量的NF-κB信号通路抑制剂。
• METHODS AND COMPOSITIONS FOR TREATING PANCREATITIS
  申请人：BAYLOR RESEARCH INSTITUTE

  公开号：US20180117067A1

  公开（公告）日：2018-05-03

  It was discovered that NF-κB signaling pathway plays a central role in pancreatitis, and inhibition of NF-κB signaling has the potential to reduce the incidence of pancreatitis and protect pancreatic tissues from inflammatory damage. Aspects of the disclosure relate to a method for inhibiting or treating pancreatitis in a subject in need thereof comprising administering a therapeutically effective amount of an NF-κB signaling pathway inhibitor to the subject.
• Targeting Innate Immune Signaling in Neuroinflammation and Neurodegeneration
  申请人：The General Hospital Corporation

  公开号：US20200308240A1

  公开（公告）日：2020-10-01

  Methods for treating neurodegenerative diseases that can include targeting TANK Binding Kinase 1 (TBK1), I kappa B kinase (IKK), Signal Transducer and Activator of Transcription 1 (STAT1), or Janus Kinase 1 or Janus Kinase 2 (Jak1/2).
• [EN] METHODS AND COMPOSITIONS FOR TREATING PANCREATITIS<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE LA PANCRÉATITE
  申请人：BAYLOR RES INST

  公开号：WO2016160880A1

  公开（公告）日：2016-10-06

  It was discovered that NF-κΒ signaling pathway plays a central role in pancreatitis, and inhibition of NF-κΒ signaling has the potential to reduce the incidence of pancreatitis and protect pancreatic tissues from inflammatory damage. Aspects of the disclosure relate to a method for inhibiting or treating pancreatitis in a subject in need thereof comprising administering a therapeutically effective amount of an NF-κΒ signaling pathway inhibitor to the subject.
• [EN] TARGETING INNATE IMMUNE SIGNALING IN NEUROINFLAMMATION AND NEURODEGENERATION<br/>[FR] CIBLAGE DE LA SIGNALISATION IMMUNITAIRE INNÉE DANS UNE NEUROINFLAMMATION ET UNE NEURODÉGÉNÉRESCENCE
  申请人：MASSACHUSETTS GEN HOSPITAL

  公开号：WO2017173451A1

  公开（公告）日：2017-10-05

  Methods for treating neurodegenerative diseases that can include targeting TANK Binding Kinase 1 (TBK1), I kappa B kinase (IKK), Signal Transducer and Activator of Transcription 1 (STAT1), or Janus Kinase 1 or Janus Kinase 2 (Jak1/2).