tert-butyl 3-(benzoyloxy)pyrrolidine-1-carboxylate | 204381-51-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl 3-(benzoyloxy)pyrrolidine-1-carboxylate
• 英文别名: Tert-butyl 3-benzoyloxypyrrolidine-1-carboxylate
• CAS: 204381-51-1
• 化学式: C₁₆H₂₁NO₄
• mdl: MFCD24393523
• 分子量: 291.347
• InChiKey: NYSYYGRFAKETOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl 3-(benzoyloxy)pyrrolidine-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到benzoic acid pirrolidin-3-yl ester
  参考文献：
  名称：

  Syntheses of new modified Phe-Pro peptides. Use of proline replacements in potential HIV inhibitors

  摘要：

  The syntheses consisting of replacement of proline amino acid by a 3-pyrrolidinone ring in Phe-Pro analogues are described. Preliminary anti-HIV studies demonstrated the potential activity of this new class of compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00006-7
• 作为产物：
  描述：

  二碳酸二叔丁酯 在 TEA 作用下， 以 二氯甲烷 为溶剂， 生成 tert-butyl 3-(benzoyloxy)pyrrolidine-1-carboxylate
  参考文献：
  名称：

  Syntheses of new modified Phe-Pro peptides. Use of proline replacements in potential HIV inhibitors

  摘要：

  The syntheses consisting of replacement of proline amino acid by a 3-pyrrolidinone ring in Phe-Pro analogues are described. Preliminary anti-HIV studies demonstrated the potential activity of this new class of compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00006-7

文献信息

• Development of a redox-free Mitsunobu reaction exploiting phosphine oxides as precursors to dioxyphosphoranes
  作者：Xiaoping Tang、Charlotte Chapman、Matthew Whiting、Ross Denton

  DOI：10.1039/c4cc02171a

  日期：——

  The development of a redox-free protocol for Mitsunobu inversion is described.

  描述了一种用于Mitsunobu反转的无氧化还原的方法。
• Stereocontrolled Pericyclic and Radical Cycloaddition Reactions of Readily Accessible Chiral Alkenyl Diazaborolidines
  作者：Mingkai Zhang、Peilin Xu、Alex J. Vendola、Christophe Allais、Anne‐Marie Dechert Schmitt、Robert A. Singer、James P. Morken

  DOI：10.1002/anie.202205454

  日期：2022.7.25

  Chiral diazaborolidines that are easily prepared, inexpensive, stable, and provide excellent stereoselection across a number of reaction classes are described. These versatile compounds can be used in four different classes of cycloaddition reactions, offering good yield and stereoselectivity.

  描述了易于制备、廉价、稳定并且在许多反应类别中提供优异的立体选择的手性二氮杂硼烷。这些多功能化合物可用于四种不同类型的环加成反应，提供良好的产率和立体选择性。
• 1-Azabicyclo(3.2.0)Hept-2-Ene-2-carboxylic acid compounds
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0394991B1

  公开（公告）日：1994-08-17
• US5102877A
  申请人：——

  公开号：US5102877A

  公开（公告）日：1992-04-07
• Syntheses of new modified Phe-Pro peptides. Use of proline replacements in potential HIV inhibitors
  作者：M. Bouygues、M. Medou、G. Quéléver、J.C. Chermann、M. Camplo、J.L. Kraus

  DOI：10.1016/s0960-894x(98)00006-7

  日期：1998.2

  The syntheses consisting of replacement of proline amino acid by a 3-pyrrolidinone ring in Phe-Pro analogues are described. Preliminary anti-HIV studies demonstrated the potential activity of this new class of compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.