申请人:Toyo Boseki Kabushiki Kaisha
公开号:EP1402871A1
公开(公告)日:2004-03-31
The present invention provides an antithrombotic composition containing an ionic complex formed from an organic cation mixture and heparin or a heparin derivative, wherein the organic cation mixture is a mixture of at least two ammonium salts, provided that the above-mentioned organic cation mixture is not a mixture of a didodecyldimethylammonium salt and at least one kind of an ammonium salt selected from ammonium salts having four aliphatic groups, wherein the four aliphatic groups have 30 to 38 carbon atoms in total and at least two of the four aliphatic groups are each an alkyl group having not less than 10 carbon atoms. This antithrombotic composition can impart superior antithrombotic property to a medical device over a prolonged period.
本发明提供了一种含有由有机阳离子混合物和肝素或肝素衍生物形成的离子复合物的抗血栓组合物,其中有机阳离子混合物是至少两种铵盐的混合物、条件是上述有机阳离子混合物不是十二烷基二甲基铵盐和至少一种选自具有四个脂肪族基团的铵盐的铵盐的混合物,其中四个脂肪族基团共有 30 至 38 个碳原子,且四个脂肪族基团中至少有两个基团分别是具有不少于 10 个碳原子的烷基。这种抗血栓组合物可为医疗设备提供长期的卓越抗血栓性能。