1-benzoyloxy-3-(2-methyl-piperidino)-propane; hydrochloride | 24561-10-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzoyloxy-3-(2-methyl-piperidino)-propane; hydrochloride
• 英文别名: 1-Benzoyloxy-3-(2-methyl-piperidino)-propan; Hydrochlorid；piperocaine hydrochloride；hydron;3-(2-methylpiperidin-1-yl)propyl benzoate;chloride
• CAS: 24561-10-2
• 化学式: C₁₆H₂₃NO₂*ClH
• 分子量: 297.825
• InChiKey: ZXSGQNYQJIUMQN-UHFFFAOYSA-N

物化性质

• 熔点：
  172-175 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.53
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氯丙基苯甲酸酯 、 alkaline earth salt of/the/ methylsulfuric acid 生成 1-benzoyloxy-3-(2-methyl-piperidino)-propane; hydrochloride
  参考文献：
  名称：

  McElvain, Journal of the American Chemical Society, 1927, vol. 49, p. 2837

  摘要：

  DOI：

文献信息

• TERPENE COUPLING CONJUGATE
  申请人：LABORATOIRES ERIGER

  公开号：US20210361771A1

  公开（公告）日：2021-11-25

  The subject matter of the present invention relates to the use of an optionally branched linear terpene having at most one C═C unsaturation for the production of conjugates provided with self-assembly properties, as well as a self-assembly agent of formula (I): X(-Spacer-Y-Terpene) p (I) in which: “Terpene” is linear, optionally branched, having at most one C═C unsaturation; “Y” is a bond or a molecular fragment with a biodegradable bond; “Spacer” is a bond or a fragment comprising at least one carbon atom; “X” is a molecular fragment comprising at least one biodegradable bond; “p” ranges between 0.1 and 4; and the “-Spacer-Y-” group optionally can be a bond, as well as the conjugate resulting from the combination of the self-assembly agent of formula (I) with an active molecule MA.

  本发明的主题涉及使用最多具有一个C═C不饱和度的线性可选择分支的萜烯，用于具有自组装特性的共轭物的生产，以及具有以下式(I)的自组装剂： X(-Spacer-Y-Terpene) p (I) 其中： “萜烯”是线性的，可选择分支的，最多具有一个C═C不饱和度； “Y”是一个具有可生物降解键的键或分子片段； “Spacer”是一个包含至少一个碳原子的键或片段； “X”是一个包含至少一个可生物降解键的分子片段； “p”范围在0.1至4之间；以及 “-Spacer-Y-”基团可以选择是一个键， 以及由式(I)的自组装剂与活性分子MA的组合产生的共轭物。
• Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of sensory discomfort
  申请人：Wei Edward T.

  公开号：US20150164924A1

  公开（公告）日：2015-06-18

  The present discovery pertains generally to the field of therapeutic compounds. More specifically the present discovery pertains to certain di-isopropyl-phosphinoyl-alkanes as described herein, DIPA-1-5, DIPA-1-6, DIPA-1-7, DIPA-1-8, and DIPA-1-9, collectively referred to herein as “DIPA compounds”, that are useful, for example, in the treatment of disorders (e.g., diseases) including: sensory discomfort (e.g., caused by irritation, itch, or pain); a skin dysesthesia; dermatitis; ocular pain and discomfort; heat discomfort; heat stress; flushing and/or night sweats (vasomotor symptoms); post-operative hypothermia; post-anaesthetic shivering; fatigue; tiredness; depression; cognitive dysfunction; and to enhance cognitive function. The applicant has found that localized delivery of DIPA compounds to the upper eyelid and/or facial skin has an alerting and enhancement effect on behavior and can be used to give a cosmetic refreshing look, to mental alertness, to reduce fatigue, and to improve work output. The present discovery also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy, in diagnosis of neuropathic pain, and in study of TRPM8 function.

  本发现通常涉及治疗化合物领域。更具体地，本发现涉及如下所述的某些二异丙基磷酰基烷烃，即DIPA-1-5、DIPA-1-6、DIPA-1-7、DIPA-1-8和DIPA-1-9，以下统称为“DIPA化合物”，这些化合物在治疗包括但不限于感觉不适（例如由刺激、瘙痒或疼痛引起）、皮肤感觉异常、皮炎、眼部疼痛和不适、热感不适、热应激、潮红和/或盗汗（血管运动症状）、术后低体温、麻醉后颤抖、疲劳、疲倦、抑郁、认知功能障碍以及增强认知功能等疾病（例如疾病）的治疗中具有用途。申请人发现将DIPA化合物局部传递至上眼睑和/或面部皮肤对行为具有警觉和增强效果，并可用于给予一种化妆上的焕然一新的外观，提高精神警觉度，减轻疲劳，并提高工作产出。本发现还涉及包含此类化合物的药物组合物，以及此类化合物和组合物的用途，例如在治疗、神经病痛诊断和TRPM8功能研究中的应用。
• [EN] DI-ISOPROPYL-PHOSPHINOYL-ALKANE (DAPA) COMPOUNDS AS TOPICAL AGENTS FOR THE TREATMENT OF SENSORY DISCOMFORT<br/>[FR] COMPOSÉS DI-ISOPROPYL-PHOSPHINOYL-ALCANES (DAPA) EN TANT QU'AGENTS TOPIQUES POUR LE TRAITEMENT D'UNE GÊNE SENSORIELLE
  申请人：WEI EDWARD TAK

  公开号：WO2015059432A1

  公开（公告）日：2015-04-30

  The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain di-isopropyl-phosphinoyl- alkanes as described herein (DIPA-1-6, DIPA-1-7, DIPA-1-8, and DIPA-1-9, collectively referred to herein as "DIPA compounds") that are useful, for example, in the treatment of disorders (e.g., diseases) including: sensory discomfort (e.g., caused by irritation, itch, or pain); a skin dysesthesia; dermatitis; psoriasis; ocular discomfort; heat discomfort; heat stress; flushing and/or night sweats (vasomotor symptoms) in post-menopausal women; post-operative hypothermia; post-anaesthetic shivering; fatigue; tiredness; depression; cognitive dysfunction; and to enhance cognitive function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy.

  本发明涉及治疗化合物领域。更具体地，本发明涉及如下所述的某些二异丙基氧代磷酰基烷烃（DIPA-1-6、DIPA-1-7、DIPA-1-8和DIPA-1-9，统称为“DIPA化合物”），例如在治疗以下疾病时有用：感觉不适（例如由刺激、瘙痒或疼痛引起）；皮肤失感；皮炎；牛皮癣；眼部不适；热不适；热应激；面部潮红和/或绝经后妇女的盗汗（血管运动症状）；术后低体温症；术后麻醉颤抖；疲劳；疲倦；抑郁；认知功能障碍；以及增强认知功能。本发明还涉及包含这种化合物的制药组合物，以及这种化合物和组合物的使用，例如在治疗中。
• Wound Dressings, Methods of Using the Same and Methods of Forming the Same
  申请人：Stasko Nathan

  公开号：US20120136323A1

  公开（公告）日：2012-05-31

  Provided according to some embodiments of the invention are wound dressings that include a polymer matrix and nitric oxide-releasing polysiloxane macromolecules within and/or on the polymer matrix. Also provided are wound dressing kits and methods of using and forming such wound dressings.

  根据本发明的某些实施例，提供了包括聚合物基质和硅氧烷聚合物中释放一氧化氮的大分子的敷料。还提供了创伤敷料套件和使用和形成这种创伤敷料的方法。
• Water-dispersible patch containing an active agent for dermal delivery
  申请人：McEntire Edward Enns

  公开号：US20070259029A1

  公开（公告）日：2007-11-08

  A dermal patch having comprising at least two layers wherein at least one layer is a polymer matrix system having an active agent admixed therein. At least one of the layers includes a water-dispersible or water-dissipatable polymer. The dermal patch has an elongation factor of at least 50%.

  一种皮肤贴片，包括至少两层，其中至少一层是聚合物基质系统，其中混合了活性剂。至少一层包括可水分散或可水分散的聚合物。该皮肤贴片的伸长系数至少为50％。