Azoture de l'acide 2-diethylphosphonoethanoique | 146036-67-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Azoture de l'acide 2-diethylphosphonoethanoique
• 英文别名: 2-Diethoxyphosphorylacetyl azide
• CAS: 146036-67-1
• 化学式: C₆H₁₂N₃O₄P
• 分子量: 221.153
• InChiKey: JDLGLEQIADMIFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  67
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Azoture de l'acide 2-diethylphosphonoethanoique 以 苯 为溶剂， 反应 2.0h， 以90.5%的产率得到(1-Isocyanato)methylphosphonate de diethyle
  参考文献：
  名称：

  Synthese de peptides modifies incorporant un motif phosphore n ou c terminal

  摘要：

  A general route to phosphopeptids with a 2-oxoalkylphosphonate moiety at the terminal N-aminogroup or with a 1-aminoalkylphosphonate moiety at the terminal C-carboxyl group is described. The method allows the preparation of various phosphopeptids with an alpha-alkylated carbon atom on the P-C bond from the very available dialkylphosphonoalcanoic acids as starting products.

  DOI：

  10.1016/s0040-4020(01)92278-1
• 作为产物：
  描述：

  氯羰基甲基膦酸二乙酯 在 sodium azide 作用下， 以 乙醚 、 水 为溶剂， 反应 2.0h， 以84%的产率得到Azoture de l'acide 2-diethylphosphonoethanoique
  参考文献：
  名称：

  Synthese de peptides modifies incorporant un motif phosphore n ou c terminal

  摘要：

  A general route to phosphopeptids with a 2-oxoalkylphosphonate moiety at the terminal N-aminogroup or with a 1-aminoalkylphosphonate moiety at the terminal C-carboxyl group is described. The method allows the preparation of various phosphopeptids with an alpha-alkylated carbon atom on the P-C bond from the very available dialkylphosphonoalcanoic acids as starting products.

  DOI：

  10.1016/s0040-4020(01)92278-1

文献信息

• ANTI-CANCER PHOSPHONATE ANALOGS
  申请人：Boojamra Constantine G.

  公开号：US20100022467A1

  公开（公告）日：2010-01-28

  The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗癌化合物、含有这些化合物的组合物以及包括给予这些化合物的治疗方法，还涉及用于制备这些化合物的过程和中间体。
• US7452901B2
  申请人：——

  公开号：US7452901B2

  公开（公告）日：2008-11-18
• Synthese de peptides modifies incorporant un motif phosphore n ou c terminal
  作者：Ph. Coutrot、C. Grison、C. Charbonnier-Gérardin

  DOI：10.1016/s0040-4020(01)92278-1

  日期：1992.11

  A general route to phosphopeptids with a 2-oxoalkylphosphonate moiety at the terminal N-aminogroup or with a 1-aminoalkylphosphonate moiety at the terminal C-carboxyl group is described. The method allows the preparation of various phosphopeptids with an alpha-alkylated carbon atom on the P-C bond from the very available dialkylphosphonoalcanoic acids as starting products.