SALRHYINLITRQRY | 718628-68-3

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: SALRHYINLITRQRY
• 英文别名: (2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
• CAS: 718628-68-3
• 化学式: C₈₅H₁₃₈N₂₈O₂₂
• 分子量: 1904.21
• InChiKey: RJIICOGGNWIKON-PIJSUOSGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  135
• 可旋转键数：
  65
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  852
• 氢给体数：
  32
• 氢受体数：
  27

反应信息

• 作为产物：
  描述：

  在 水 、 三(2-羰基乙基)磷盐酸盐 作用下， 反应 0.5h， 生成 SALRHYINLITRQRY
  参考文献：
  名称：

  Switch Peptide via Staudinger Reaction

  摘要：

  A new transformation based on the Staudinger reaction is described, and its application in the design of a novel switch element to control peptide folding is demonstrated. We found that the azide switch is activated rapidly in water to promote acyl transfer using tris(2-carboxyethyl)phosphine hydrochloride (TCEP) via the Staudinger reaction. Our findings expand the repertoire of uses of the Staudinger reaction in chemical biology and the number of available triggers for use in switch peptides.

  DOI：

  10.1021/ol802268e

文献信息

• Switch Peptide via Staudinger Reaction
  作者：Natalia Nepomniaschiy、Valerie Grimminger、Aviv Cohen、Saviana DiGiovanni、Hilal A. Lashuel、Ashraf Brik

  DOI：10.1021/ol802268e

  日期：2008.11.20

  A new transformation based on the Staudinger reaction is described, and its application in the design of a novel switch element to control peptide folding is demonstrated. We found that the azide switch is activated rapidly in water to promote acyl transfer using tris(2-carboxyethyl)phosphine hydrochloride (TCEP) via the Staudinger reaction. Our findings expand the repertoire of uses of the Staudinger reaction in chemical biology and the number of available triggers for use in switch peptides.