2-fluoro-N-(5-(hydroxymethyl)-6'-phenyl-[2,3-bipyridin]-5'-yl)-5-(pyrimidin-2-yl)-4-(trifluoromethyl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-fluoro-N-(5-(hydroxymethyl)-6'-phenyl-[2,3-bipyridin]-5'-yl)-5-(pyrimidin-2-yl)-4-(trifluoromethyl)benzamide
• 英文别名: 2-fluoro-N-(5-(hydroxymethyl)-6''-phenyl-[2,3''-bipyridin]-5''-yl)-5-(pyrimidin-2-yl)-4-(trifluoromethyl)benzamide；2-fluoro-N-[5-[5-(hydroxymethyl)pyridin-2-yl]-2-phenylpyridin-3-yl]-5-pyrimidin-2-yl-4-(trifluoromethyl)benzamide
• 化学式: C₂₉H₁₉F₄N₅O₂
• 分子量: 545.496
• InChiKey: DZAHOTGVPUBAGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP3122346A2

  公开（公告）日：2017-02-01
• US9815846B2
  申请人：——

  公开号：US9815846B2

  公开（公告）日：2017-11-14
• [EN] TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF<br/>[FR] INHIBITEURS DE LA KINASE TRKA, COMPOSITIONS EN CONTENANT ET MÉTHODES ASSOCIÉES
  申请人：MERCK SHARP & DOHME

  公开号：WO2015148344A2

  公开（公告）日：2015-10-01

  The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.