5-Benzylidene-3-ethylrhodanine | 18331-34-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-Benzylidene-3-ethylrhodanine
• 英文别名: (5E)-5-benzylidene-3-ethyl-2-sulfanylidene-1,3-thiazolidin-4-one
• CAS: 18331-34-5
• 化学式: C₁₂H₁₁NOS₂
• 分子量: 249.4
• InChiKey: ZQDPYAPUFMILTB-CSKARUKUSA-N

物化性质

• 熔点：
  150 °C
• 沸点：
  372.8±45.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)
• 溶解度：
  DMSO：25 mg/mL (100.26 mM)；水：< 0.1 mg/mL（不溶）

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  77.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

生物活性

BTR-1 是一种活性抗癌剂，能够诱导细胞周期 S 期停滞，影响 DNA 复制，并激活凋亡 (apoptosis)，导致细胞死亡。

靶点

Apoptosis

体外研究

在人类白血病细胞中，BTR-1（10、50、100 和 250 µM，持续 5 天）浓度依赖性地引起细胞毒性。IC₅₀ 值分别为 8 和 6 µM，在 48 小时和 72 小时分别测定。

细胞活力测定

• 细胞系： T 细胞白血病细胞系
• 浓度： 10、50、100 和 250 µM
• 孵育时间： 5 天
• 结果： 浓度依赖性地诱导人类白血病细胞的细胞毒性。

文献信息

• Image forming method using photothermographic material
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP1519224A2

  公开（公告）日：2005-03-30

  An image forming method applying X-ray exposure to a photothermographic material having, on at least one surface of a support, an image forming layer containing at least a photosensitive silver halide, a non-photosensitive organic silver salt, a reducing agent for silver ions, and a binder, wherein the photothermographic material is brought into close contact with a fluorescence intensifying screen containing a fluorescent material that emits light, 50% or more of which has a wavelength in a range of 350 nm or more and 420 nm or less.

  一种图像形成方法，将 X 射线照射到光热成像材料上，该材料至少在支撑物的一个表面上有一个图像形成层，该图像形成层至少含有光敏卤化银、非光敏有机银盐、银离子还原剂和粘合剂，其中光热成像材料与荧光增亮屏紧密接触，该荧光增亮屏含有一种荧光材料，该荧光材料能发光，其中 50%或更多的光波长在 350 nm 或更高和 420 nm 或更低的范围内。
• Medical image file management system
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP1517175A1

  公开（公告）日：2005-03-23

  A medical image file management system for managing an image film showing a captured diagnostic image of a corresponding patient, the system comprising: at least one wireless tag (2) to be attached to the image film (1); and a wireless tag read/write apparatus that writes, into at least one of said at least one wireless tag (2), first information selected from at least one of patient information, checkup information, photographing condition information and filmprocessing information, by means of effecting transmission and receipt with said at least one wireless tag attached to the image film (1).

  一种医疗图像文件管理系统，用于管理显示所拍摄的相应患者诊断图像的图像胶片，该系统包括：至少一个无线标签（2），用于连接到图像胶片（1）上；以及一个无线标签读/写装置，通过与连接到图像胶片（1）上的至少一个无线标签进行传输和接收，将选自患者信息、检查信息、拍摄条件信息和胶片处理信息中至少一种的第一信息写入所述至少一个无线标签（2）中的至少一个。
• ANTI-NEURODEGENERATIVE DISEASE AGENT
  申请人：Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

  公开号：EP2397139A1

  公开（公告）日：2011-12-21

  The present invention has an object to provide a novel agent for anti-neurodegenerative diseases and solves the object by providing an agent for anti-neurodegenerative diseases containing, as an effective ingredient, the compound(s) represented by the following General formula 1: wherein in General formula 1, R1 through R3 independently represent a hydrogen atom or an appropriate substituent; Z1 represents a heterocyclic ring and Z2 represents the same or different heterocyclic or aromatic ring as in Z1, wherein the heterocyclic and aromatic rings optionally have a substituent; o represents an integer of 0, 1 or 2; p represents an integer of 0 or 1, with the proviso that p is 1 when o is 0 or 2, and p is 0 when o is 1; R1 and R2 do not exist when o is 0, while, when p is 0, R3 does not exist and the binding between the carbon atom to which R2 binds and Z2 is a single bond; X1- represents an appropriate counter anion and q represents an integer of 1 or 2.

  本发明的目的是提供一种抗神经退行性疾病的新型制剂，并通过提供一种抗神经退行性疾病的制剂来解决该目的，该制剂含有以下通式 1 所代表的化合物作为有效成分： 其中在通式 1 中，R1 至 R3 独立地代表氢原子或适当的取代基；Z1 代表杂环，Z2 代表与 Z1 相同或不同的杂环或芳香环，其中杂环和芳香环可选择具有取代基；o 代表 0、1 或 2 的整数；当 o 为 0 时，R1 和 R2 不存在，而当 p 为 0 时，R3 不存在，R2 所结合的碳原子与 Z2 之间的结合为单键；X1- 代表适当的反阴离子，q 代表 1 或 2 的整数。
• Silver halide emulsion, production process thereof and novel pyridinium compound
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：US20020155399A1

  公开（公告）日：2002-10-24

  A silver halide emulsion comprising tabular grains having a very small thickness with the main surfaces thereof having a very large surface area and being (111) face, is disclosed. More specifically, a silver halide emulsion is disclosed, comprising light-sensitive silver halide grains having a silver bromide content of 70 mol % or more, with 60% or more of the entire projected area of said silver halide grains being occupied by tabular grains having an average grain thickness of less than 0.04 &mgr;m, an average equivalent-circle diameter of 4 &mgr;m or more, and (111) face as main surfaces.

  本发明公开了一种卤化银乳剂，它由厚度极小的片状颗粒组成，其主要表面具有非常大的表面积，并且是（111）面。 更具体地说，本发明公开了一种卤化银乳液，它由溴化银含量大于等于 70 摩尔%的光敏卤化银颗粒组成，所述卤化银颗粒的整个投影面积的 60% 或更多被平均颗粒厚度小于 0.04 微米、平均等效圆直径大于等于 4 微米、主表面为（111）面的片状颗粒所占据。
• Medical image file management system and medical image film
  申请人：Ito Tomohiko

  公开号：US20050098619A1

  公开（公告）日：2005-05-12

  A medical image file management system for managing an image film showing a captured diagnostic image of a corresponding patient, the system comprising: at least one wireless tag to be attached to the image film; and a wireless tag read/write apparatus that writes, into at least one of said at least one wireless tag, first information selected from at least one of patient information, checkup information, photographing condition information and film processing information, by means of effecting transmission and receipt with said at least one wireless tag attached to the image film.

  一种医学影像文件管理系统，用于管理显示所拍摄的相应患者诊断影像的影像胶片，该系统包括：至少一个无线标签，用于附着在影像胶片上；以及无线标签读/写装置，通过与附着在影像胶片上的所述至少一个无线标签进行传输和接收，将选自患者信息、检查信息、拍摄条件信息和胶片处理信息中至少一种的第一信息写入所述至少一个无线标签的至少一个标签中。