6-Brom-1,4-dimethyl-1,4-dihydro-chinoxalin-2,3-dion | 1770-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-Brom-1,4-dimethyl-1,4-dihydro-chinoxalin-2,3-dion
• 英文别名: 6-Brom-1.2.3.4-tetrahydro-1.4-dimethyl-2.3-dioxo-chinoxalin；6-bromo-1,4-dimethyl-1,4-dihydro-quinoxaline-2,3-dione；6-Bromo-1,4-dimethyl-1,4-dihydroquinoxaline-2,3-dione；6-bromo-1,4-dimethylquinoxaline-2,3-dione
• CAS: 1770-36-1
• 化学式: C₁₀H₉BrN₂O₂
• mdl: MFCD00957063
• 分子量: 269.098
• InChiKey: JKFMIMJEBVNKOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  一氧化碳 、 6-Brom-1,4-dimethyl-1,4-dihydro-chinoxalin-2,3-dion 在 dicobalt octacarbonyl potassium carbonate 、 methyloxirane 、 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以49%的产率得到1,4-dimethyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylic acid
  参考文献：
  名称：

  Synthesis of heteroaromatic carboxylic acids by carbonylation of hetaryl halides with catalysts based on cobalt carbonyl modified with epoxides

  摘要：

  A new method for the synthesis of heteroaromatic acids and their derivatives (esters and salts) by carbonylation of the corresponding halides was developed. Hetaryl halides were activated in alcoholic-alkali medium by highly active catalytic systems based on cobalt carbonyl modified with epoxides, developed previously for carbonylation of aryl halides.

  DOI：

  10.1134/s1070427207040106
• 作为产物：
  描述：

  N-(4-溴-2-硝基苯基)乙酰胺 在 盐酸 、 sodium hydroxide 、 硫酸二甲酯 、 tin(ll) chloride 作用下， 生成 6-Brom-1,4-dimethyl-1,4-dihydro-chinoxalin-2,3-dion
  参考文献：
  名称：

  275.合成抗疟药。第XL部分。2-氯-3 - β-二乙基氨基乙基氨基喹喔啉中取代基变化的影响

  摘要：

  DOI：

  10.1039/jr9490001271

文献信息

• [EN] FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF<br/>[FR] MODULATEURS DE LA FERROPTOSE, PRÉPARATIONS ET UTILISATIONS ASSOCIÉES
  申请人：[en]SIRONAX LTD.

  公开号：WO2023280296A1

  公开（公告）日：2023-01-12

  Provided are compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating various diseases and conditions, e.g., those involving ferroptosis.
• Synthesis of heteroaromatic carboxylic acids by carbonylation of hetaryl halides with catalysts based on cobalt carbonyl modified with epoxides
  作者：V. P. Boyarskii、T. E. Zhesko、E. V. Larionov、V. A. Polukeev

  DOI：10.1134/s1070427207040106

  日期：2007.4

  A new method for the synthesis of heteroaromatic acids and their derivatives (esters and salts) by carbonylation of the corresponding halides was developed. Hetaryl halides were activated in alcoholic-alkali medium by highly active catalytic systems based on cobalt carbonyl modified with epoxides, developed previously for carbonylation of aryl halides.
• 275. Synthetic antimalarials. Part XL. The effect of variation of substituents in 2-chloro-3-β-diethylaminoethylaminoquinoxaline
  作者：F. H. S. Curd、D. G. Davey、G. J. Stacey

  DOI：10.1039/jr9490001271

  日期：——