4-[4-[[[(1R)-1-isoquinolin-8-ylethyl]amino]methyl]phenyl]-2-methoxybenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-[[[(1R)-1-isoquinolin-8-ylethyl]amino]methyl]phenyl]-2-methoxybenzoic acid
• 化学式: C₂₆H₂₄N₂O₃
• 分子量: 412.5
• InChiKey: WEMWZILHNLCISU-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  71.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Targeting AMP deaminase 2 for ameliorating craving for sugar and other substances
  申请人：The Regents of the University of Colorado, a body coporate

  公开号：US10912770B2

  公开（公告）日：2021-02-09

  The invention relates to the use of adenosine monophosphate deaminase 2 (AMPD2) inhibitors alone or in combination with various agents to treat a wide variety of diseases including, but not limited to, sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions. Embodiments of the invention may also relate to stimulation of AMPD2 activity to treat anorexia nervosa or stimulate food intake in a subject.

  本发明涉及单磷酸腺苷脱氨酶2（AMPD2）抑制剂单独使用或与各种制剂联合使用来治疗多种疾病，包括但不限于糖瘾、盐瘾、味觉瘾以及包括药物、烟草、尼古丁和酒精成瘾在内的成瘾。本发明的实施方案还可能涉及刺激 AMPD2 的活性，以治疗神经性厌食症或刺激受试者的食物摄入量。
• TARGETING AMP DEAMINASE 2 FOR AMELIORATING CRAVING FOR SUGAR AND OTHER SUBSTANCES
  申请人：The Regents of the University of Colorado, A Body Corporate

  公开号：US20190117642A1

  公开（公告）日：2019-04-25

  The invention relates to the use of adenosine monophosphate deaminase 2 (AMPD2) inhibitors alone or in combination with various agents to treat a wide variety of diseases including, but not limited to, sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions. Embodiments of the invention may also relate to stimulation of AMPD2 activity to treat anorexia nervosa or stimulate food intake in a subject.