2-(trichloromethyl)-3-chloropyridine | 1817-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(trichloromethyl)-3-chloropyridine
• 英文别名: 3-Chlor-trichlormethylpyridin；3-chloro-2-trichloromethyl pyridine；Chloro trichloromethyl pyridine；3-chloro-2-(trichloromethyl)pyridine
• CAS: 1817-12-5
• 化学式: C₆H₃Cl₄N
• 分子量: 230.909
• InChiKey: XAYLRCRXDBZOBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  碳酸甲丙酯 生成 2-(trichloromethyl)-3-chloropyridine
  参考文献：
  名称：

  MARINAK, M. J.;SIMONSON, J. L.

  摘要：

  DOI：

文献信息

• PREPARATION OF 3,6-DICHLORO-2-TRICHLOROMETHYLPYRIDINE BY VAPOR PHASE CHLORINATION OF 6-CHLORO-2-TRICHLOROMETHYLPYRIDINE
  申请人：——

  公开号：US20040176607A1

  公开（公告）日：2004-09-09

  A mixture containing 5,6-dichloro-2-trichloromethylpyridine and 3,6-dichloro-2-trichloromethylpyridine enriched in 3,6-dichloro-2-trichloromethylpyridine is obtained by chlorinating 6-chloro-2-trichloromethylpyridine in the vapor phase using a Type L zeolite catalyst.

  使用L型沸石催化剂，在气相中氯化6-氯-2-三氯甲基吡啶，得到含有5,6-二氯-2-三氯甲基吡啶和3,6-二氯-2-三氯甲基吡啶的混合物，其中3,6-二氯-2-三氯甲基吡啶得到了富集。
• Process for preparing 2,3,5,6-tetrachloropyridine
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0005064A1

  公开（公告）日：1979-10-31

  2,3,5,6-Tetrachloropyridine and pentachloropyridine are prepared by reacting a chlorosubstituted (trichloromethyl) pyridine in the liquid state with chlorine at temperatures of at least about 160°C in the presence of a Lewis acid type catalyst. The products are useful as intermediates for the preparation of herbicides and pesticides.

  2,3,5,6-四氯吡啶和五氯吡啶是在路易斯酸型催化剂存在下，在至少约 160°C 的温度下，通过液态氯代（三氯甲基）吡啶与氯反应制备而成。这些产品可用作制备除草剂和杀虫剂的中间体。
• Preparation of polychlorinated pyridines from 2,4-dichloro-6-(trichloromethyl)pyridine
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0007160A1

  公开（公告）日：1980-01-23

  Pentachloropyridine and polychloro derivatives of 2-(trichloromethyl)pyridine are prepared by reacting 2,4- diohloro-6-(trichloromethyl)pyridine in the liquid state with chlorine at temperatures of at least 160°C in the presence of a Lewis acid type catalyst. The products ara useful as herbicides, pesticides, or as chemical intermediates for the preparation of other products useful, for example, as herbicides or . pesticides.

  2- (三氯甲基)吡啶的五氯吡啶和多氯衍生物是在路易斯酸型催化剂存在下，在至少 160°C 的温度下，通过使液态的 2,4-二氯-6-(三氯甲基)吡啶与氯反应而制备的。这些产品可用作除草剂、杀虫剂，或用作制备其他产品（例如除草剂或杀虫剂）的化学中间体。
• Vapor phase production of Chlorinated pyridines from alpha-picoline
  申请人：MAKHTESHIM CHEMICAL WORKS LIMITED

  公开号：EP0239905A1

  公开（公告）日：1987-10-07

  2-Chloropyridine, 2,6-dichloropyridine, 2,3,6-trichloropyridine, and 2,3,5,6-tetrachloropyridine are prepared by reacting alpha-picoline in the gas phase with chlorine attemperature from about 200°C in the presence of water and an amount of catalyst effective to catalyze the reaction.

  2-氯吡啶、2,6-二氯吡啶、2,3,6-三氯吡啶和 2,3,5,6-四氯吡啶是通过气相中的α-甲基吡啶与氯在温度约为 200°C 的条件下，在水和一定量的催化剂催化下反应制备的。
• Control of isomer distribution in a chlorination process
  申请人：DOWELANCO

  公开号：EP0420356A2

  公开（公告）日：1991-04-03

  The relative amounts of 5,6-dichloro-2-(tri­chloromethyl)pyridine and 3,6-dichloro-2-(trichloro­methyl)pyridine obtained in the chlorination of 2-chloro-6-(trichloromethyl)pyridine in the liquid phase at temperatures of 160°C to 220°C and in the presence of a metal halide catalyst, such as ferric chloride are controlled by regulating the amount of hydrogen chloride present in the system, adding hydrogen chloride to obtain a mixture enriched in 5,6-dichloro-2-(trichloro­methyl)pyridine or removing hydrogen chloride, usually by passing excess chlorine or an inert gas through the system, to obtain a mixture enriched in 3,6-dichloro-2-­(trichloromethyl)pyridine.

  在 160°C 至 220°C 温度和金属卤化物催化剂存在下，在液相中对 2-氯-6-(三氯甲基)吡啶进行氯化反应，可获得 5,6-二氯-2-(三氯甲基)吡啶和 3,6-二氯-2-(三氯甲基)吡啶的相对量、控制方法包括调节系统中氯化氢的含量、加入氯化氢以获得富含 5,6-二氯-2-(三氯甲基)吡啶的混合物，或去除氯化氢（通常是通过在系统中通入过量的氯或惰性气体）以获得富含 3,6-二氯-2-(三氯甲基)吡啶的混合物。