6-amino-2,2-dimethyl-2,3-dihydroperimidine | 374540-46-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-amino-2,2-dimethyl-2,3-dihydroperimidine
• 英文别名: 6-Amino-2,2-dimethyl-2,3-dihydro-perimidine；2,2-dimethyl-1,3-dihydroperimidin-6-amine
• CAS: 374540-46-2
• 化学式: C₁₃H₁₅N₃
• 分子量: 213.282
• InChiKey: GQDUMJIOEDJYNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  50.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-amino-2,2-dimethyl-2,3-dihydroperimidine 、 碘甲烷 在 氢氧化钾 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Dimethyl-(1,2,2,3-tetramethyl-2,3-dihydro-1H-perimidin-6-yl)-amine
  参考文献：
  名称：

  摘要：

  Efficient procedures were developed for the two-step synthesis of 1,2,2,3-tetramethyl-2,3-dihydroperimidines and for the one-step synthesis of 1,3-dimethyl-2,3-dihydroperimidines starting from 1,8-diaminonaphthalenes. New possibilities of the use of 2,3-dihydroperimidinium salts in the synthesis of 1,8-bis(dialkylamino) naphthalenes ("proton sponges") containing the IV-isopropyl group along with the A-methyl groups were demonstrated. The 1,1,2,2,3-pentamethyl-2,3-dihydroperimidinium cation exists in the acyclic iminium form responsible for its high reactivity.

  DOI：

  10.1023/a:1011359109826
• 作为产物：
  描述：

  naphthalene-1,4,8-triamine 、 丙酮 以100%的产率得到6-amino-2,2-dimethyl-2,3-dihydroperimidine
  参考文献：
  名称：

  摘要：

  Efficient procedures were developed for the two-step synthesis of 1,2,2,3-tetramethyl-2,3-dihydroperimidines and for the one-step synthesis of 1,3-dimethyl-2,3-dihydroperimidines starting from 1,8-diaminonaphthalenes. New possibilities of the use of 2,3-dihydroperimidinium salts in the synthesis of 1,8-bis(dialkylamino) naphthalenes ("proton sponges") containing the IV-isopropyl group along with the A-methyl groups were demonstrated. The 1,1,2,2,3-pentamethyl-2,3-dihydroperimidinium cation exists in the acyclic iminium form responsible for its high reactivity.

  DOI：

  10.1023/a:1011359109826

文献信息

• [EN] COMPOUND FOR PREVENTING OR TREATING LIPID METABOLISM-RELATED DISEASES<br/>[FR] COMPOSÉ POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES LIÉES AU MÉTABOLISME LIPIDIQUE<br/>[ZH] 用于预防或治疗脂质代谢相关疾病的化合物
  申请人：UNIV FUDAN

  公开号：WO2021213518A1

  公开（公告）日：2021-10-28

  本发明涉及生物医药领域，并且具体地涉及将能够结合LC3的结构与能够结合脂滴的结构通过共价连接连接在一起，从而形成的"LC3结合部分-脂滴结合部分-偶联物"，其药学上可接受的盐、立体异构体、溶剂化物、多晶型、互变异构体、同位素化合物、代谢产物或前药，以及在制备用于预防或治疗脂质代谢相关疾病的药物中的用途。
• Multi-Path Quenchers: Efficient Quenching of Common Fluorophores
  作者：Pete Crisalli、Eric T. Kool

  DOI：10.1021/bc200424r

  日期：2011.11.16

  Fluorescence quenching groups are widely employed in biological detection, sensing, and imaging. To date, a relatively small number of such groups are in common use. Perhaps the most commonly used quencher, dabcyl, has limited efficiency with a broad range of fluorophores. Here, we describe a molecular approach to improve the efficiency of quenchers by increasing their electronic complexity. Multi-Path Quenchers (MPQ) are designed to have multiple donor or acceptor groups in their structure, allowing for a multiplicity of conjugation pathways of varied length. This has the effect of broadening the absorption spectrum, which in turn can increase quenching efficiency and versatility. Six such MPQ derivatives are synthesized and tested for quenching efficiency in a DNA hybridization context. Duplexes placing quenchers and fluorophores within contact distance or beyond this distance are used to measure quenching via contact or FRET mechanisms. Results show that several of the quenchers are considerably more efficient than dabcyl at quenching a wider range of. common fluorophores, and two quench fluorescein and TAMRA as well as or better than a Black Hole Quencher.
• DYEING COMPOSITION COMPRISING A POLYCONDENSATE OF ETHYLENE OXIDE AND PROPYLENE OXIDE
  申请人：L'Oréal

  公开号：EP2515842B1

  公开（公告）日：2020-04-29
• ——
  作者：V. A. Ozeryanskii、E. A. Filatova、V. I. Sorokin、A. F. Pozharskii

  DOI：10.1023/a:1011359109826

  日期：——

  Efficient procedures were developed for the two-step synthesis of 1,2,2,3-tetramethyl-2,3-dihydroperimidines and for the one-step synthesis of 1,3-dimethyl-2,3-dihydroperimidines starting from 1,8-diaminonaphthalenes. New possibilities of the use of 2,3-dihydroperimidinium salts in the synthesis of 1,8-bis(dialkylamino) naphthalenes ("proton sponges") containing the IV-isopropyl group along with the A-methyl groups were demonstrated. The 1,1,2,2,3-pentamethyl-2,3-dihydroperimidinium cation exists in the acyclic iminium form responsible for its high reactivity.