(2RS)-1-amino-3-ethylpentan-2-ol | 72799-69-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2RS)-1-amino-3-ethylpentan-2-ol
• 英文别名: 1-amino-3-ethylpentan-2-ol
• CAS: 72799-69-0
• 化学式: C₇H₁₇NO
• mdl: MFCD14624425
• 分子量: 131.218
• InChiKey: NGNXQZFLANJCHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(4-chlorophenyl)-2-(3-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid 、 (2RS)-1-amino-3-ethylpentan-2-ol 在 1-丙基磷酸酐 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以45%的产率得到6-(4-chlorophenyl)-N-[(2RS)-3-ethyl-2-hydroxypentyl]-2-(3-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide
  参考文献：
  名称：

  [EN] 3-OXO-2,6-DIPHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES
  [FR] 3-OXO-2,6-DIPHÉNYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES

  摘要：

  本发明涵盖了一般式(I)的3-氧代-2,6-二苯基-2,3-二氢吡啶嗪-4-羧酰胺化合物：其中R1、R2、R3、R4、R5和R6如本文所定义，制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包括所述化合物的药物组合物和组合物，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是癌症或与异常AHR信号传导相关的疾病，或与10种不规则免疫反应或其他与异常AHR信号传导相关的疾病的情况，作为单一药剂或与其他活性成分结合使用。

  公开号：

  WO2017202816A1
• 作为产物：
  描述：

  2-乙基丁醛 在 lithium aluminium tetrahydride 、 zinc(II) iodide 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 (2RS)-1-amino-3-ethylpentan-2-ol
  参考文献：
  名称：

  芳环在肾上腺素胺中的重要性。5.作为苯基乙醇胺N-甲基转移酶抑制剂的苯基乙醇胺的非芳族类似物：疏水和空间相互作用的作用。

  摘要：

  DOI：

  10.1021/jm00133a003

文献信息

• Method of improving the electrical conductivity of a shaped resin article and an electrostatic coating process
  申请人：DAI-ICHI KOGYO SEIYAKU CO., LTD.

  公开号：EP0732706A2

  公开（公告）日：1996-09-18

  A nitrogen-containing compound of the following general formula (1) is kneaded into a resin molding material, the kneaded mixture is molded and the surface of the resulting article is subjected to corona discharge treatment. Further, a coating material having electrostatic charges is sprayed and deposited on the article after the corona discharge treatment. This can provide a shaped resin article with remarkably improved electrical conductivity from a less electrically conductive resin, without substantially deteriorating the physical properties and the color of the article. Further, electrostatic coating excellent in coating efficiency, surface appearance, productivity or the like is possible. where R1 represents an alkyl group or alkenyl group of 5 to 21 carbon atoms, R2 represents -H or -CH3, R3 and R4 may be the same or different and each represents an alkyl group of 1 to 4 carbon atoms, A represents -(CH2)n- or and n is 1 to 5.

  将以下通式（1）的含氮化合物捏合到树脂成型材料中，然后将捏合混合物成型，并对成型物品的表面进行电晕放电处理。此外，在电晕放电处理后，在制品上喷涂和沉积具有静电荷的涂层材料。这样就可以用导电性较差的树脂制成导电性能显著提高的成型树脂制品，而不会严重影响制品的物理性能和颜色。此外，静电涂层在涂层效率、表面外观、生产率等方面也有可能得到改善。 其中 R1 代表 5 至 21 个碳原子的烷基或烯基，R2 代表-H 或-CH3，R3 和 R4 可以相同或不同，且各自代表 1 至 4 个碳原子的烷基，A 代表-(CH2)n- 或-(CH2)n-，n 为 1 至 5。 且 n 为 1 至 5。
• AMINE CATALYST FOR CURING POLYISOCYANATE COMPOUND AND POLYISOCYANATE ADHESIVE COMPOSITION CONTAINING AMINE CATALYST FOR CURING POLYISOCYANATE COMPOUND
  申请人：Tosoh Corporation

  公开号：EP2878609A1

  公开（公告）日：2015-06-03

  To provide an amine catalyst for curing a polyisocyanate which can satisfy both initial moldability before a thermal compression step and high reactivity at the time of thermal compression molding, and an adhesive composition containing it. A catalyst comprising an amine compound (1) represented by the formula (1) and an amine compound (2) represented by the formula (2) is used as an amine catalyst for curing a polyisocyanate compound. wherein each of R1 and R2 which are independent of each other, is a C1-4 hydrocarbon group, and R3 is a C1-4 hydrocarbon group having a hydroxy group or an amino group; wherein each of R4 and R5 which are independent of each other, is a C1-4 hydrocarbon group, R6 is a C1-4 hydrocarbon group or a C1-4 hydrocarbon group having a hydroxy group or an amino group, R7 is a C1-4 hydrocarbon group having a hydroxy group or an amino group, and m is an integer of from 2 to 6.

  目的 提供一种用于固化多异氰酸酯的胺催化剂，该催化剂既能满足热压步骤前的初始模 塑性，又能满足热压成型时的高反应活性，并提供一种含有该催化剂的粘合剂组合物。 由式（1）表示的胺化合物（1）和式（2）表示的胺化合物（2）组成的催化剂用作固化多异氰酸酯化合物的胺催化剂。 其中相互独立的 R1 和 R2 均为 C1-4 烃基，R3 为具有羟基或氨基的 C1-4 烃基； 其中相互独立的R4和R5各自是C1-4烃基，R6是C1-4烃基或具有羟基或氨基的C1-4烃基，R7是具有羟基或氨基的C1-4烃基，m是2至6的整数。
• 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US11040035B2

  公开（公告）日：2021-06-22

  The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

  本发明涉及通式(I)的 3-氧代-2,6-二苯基-2,3-二氢哒嗪-4-甲酰胺化合物：其中 R1、R2、R3、R4、R5 和 R6 如本文所定义；制备所述化合物的方法；用于制备所述化合物的中间体化合物；包含所述化合物的药物组合物和组合物；以及使用所述化合物制造药物组合物，用于治疗或预防疾病，特别是癌症或免疫反应失调的病症或与异常 AHR 信号转导相关的其他疾病，作为单独制剂或与其他活性成分组合使用。
• Aqueous polyurethane dispersions
  申请人：Reiners Juergen

  公开号：US20050222368A1

  公开（公告）日：2005-10-06

  Polyurethane which is obtainable by reacting a) an NCO-containing prepolymer composed of a1) at least one polyesterpolyol, preferably polycarbonatepolyol, carbonate group-free polyesterpolyol, polyestercarbonatepolyol, polyesteramidepolyol, in particular polyesterdiol, having an average molecular weight, determined as the number average, greater than or equal to 500 g/mol, preferably from 500 to 6000 g/mol, in particular from 500 to 4000 g/mol, very particularly preferably from 800 to 4000 g/mol, and a2) at least one polyetherpolyol which differs from a1) and is preferably polyalkylene glycol, such as polyethylene glycol, polypropylene glycol, polytetramethylene glycol, polyhexamethylene glycol and copolyethers, in particular those containing building blocks from the group consisting of ethyleneoxy, propyleneoxy, tetramethyleneoxy and/or hexamethyleneoxy, having a molecular weight, determined as the number average, greater than or equal to 500, preferably from 500 to 10 000 g/mol, in particular from 500 to 4000, particularly preferably from 800 to 4000, g/mol, preferably a polyetherdiol, and a3) at least one polyol, in particular diol, having a molecular weight of less than 500 g/mol, which carries one or more ionic groups and/or one or more potentially ionic groups, preferably carries one or more carboxylate groups, and a4) at least one aliphatic polyisocyanate, preferably diisocyanate, preferably having a molecular weight of less than 500 g/mol, in particular from 112 to 400 g/mol, particularly preferably from 168 to 262 g/mol, and a5) optionally a nonionic polyol, preferably diol having a molecular weight of less than 500 g/mol, preferably from 61 to 499 g/mol, and a6) optionally a monoalcohol with b) at least one polysiloxane reactive towards NCO groups and having a molecular weight, determined as the number average, of less than 1500 g/mol, preferably having 1 to 6, in particular 1 to 3, amino and/or hydroxyl groups reactive towards NCO groups, in particular amino groups, and c) at least one amine reactive towards NCO groups and having an average amino functionality of from 1 to 6 and a molecular weight of less than 500 g/mol (molecular weight determined as the number average), which may be substituted by hydroxyl groups and/or sulpho groups and/or carboxyl groups, and d) water, the molar ratio of the hydroxy-functional compounds used for the preparation of the prepolymer a) to the polyisocyanate being from 1: 1.1 to 1: 2.5, preferably from 1.1:1 to 1: 1.7.

  a) 含 NCO 的预聚物，该预聚物由以下物质反应而成： a1) 至少一种聚酯多元醇，优选聚碳酸酯多元醇、无碳酸酯基聚酯多元醇、聚酯碳酸酯多元醇、聚酯酰胺多元醇，特别是聚酯二醇，其平均分子量大于或等于 500 克/摩尔，优选 500 至 6000 克/摩尔，特别是 500 至 4000 克/摩尔，尤其优选 800 至 4000 克/摩尔、a2) 至少一种聚醚多元醇，它不同于 a1)，最好是聚亚烷基二醇、如聚乙二醇、聚丙二醇、聚四亚甲基乙二醇、聚六亚甲基乙二醇和共聚物，特别是含有由乙 烯氧基、丙烯氧基、四亚甲基氧基和/或六亚甲基氧基组成的组中的结构单元的共聚物，其 分子量为：(1)(2)(3)(4)(5)(6)、a3) 至少一种分子量小于 500 克/摩尔的多元醇，特别是二元醇、a4) 至少一种脂肪族多异氰酸酯，最好是二异氰酸酯，分子量最好小于 500 g/mol，特别是 112 至 400 g/mol、a5) 可选的非离子多元醇，最好是分子量小于 500 克/摩尔，最好是 61 至 499 克/摩尔的二元醇，以及 a6) 可选的一元醇、b) 至少一种对 NCO 基团有反应性且分子量（按平均数计算）小于 1500 克/摩尔的聚硅氧烷，最好具有 1 至 6 个，特别是 1 至 3 个对 NCO 基团有反应性的氨基和/或羟基，尤其是氨基，以及 c) 至少一种对 NCO 基团有反应性且平均氨基官能度为 1 至 6 个且分子量小于 500 克/摩尔（分子量按平均数计算）的胺、d) 水，用于制备预聚物 a) 的羟基官能团化合物与多异氰酸酯的摩尔比为 1：1.1至1: 2.5，最好为1.1:1至1: 1.7。
• PROCEDE DE DEDOUBLEMENT DE COMPOSES 1-AMINO-ALCAN-2-OL
  申请人：UNIVERSITE DE ROUEN

  公开号：EP0946467A1

  公开（公告）日：1999-10-06