N-(2,4-dimethylphenyl)-5-oxo-1-sulfanylidene-4H-[1,3]thiazolo[3,4-a]quinazoline-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,4-dimethylphenyl)-5-oxo-1-sulfanylidene-4H-[1,3]thiazolo[3,4-a]quinazoline-3-carboxamide
• 化学式: C₁₉H₁₅N₃O₂S₂
• 分子量: 381.5
• InChiKey: ZKVMWXUMYNLGBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Methods and compositions related to STK1-targeted small molecules as antibiotic resistance breakers
  申请人：Ohio State Innovation Foundation

  公开号：US11318141B2

  公开（公告）日：2022-05-03

  Disclosed are methods and compositions related to STK1 inhibitors, such as Inh2-B1 (methyl 5-oxo-3-(phenyl carbamoyl)-1-thioxo-4,5dihydro[1,3]thiazolo[3,4-a]quinazoline-8-carboxylate). The STK1 inhibitors can act as an antibiotic resistance breakers against multidrug-resistant Staphylococcus aureus.

  公开了与 STK1 抑制剂有关的方法和组合物，如 Inh2-B1（5-氧代-3-（苯基氨基甲酰基）-1-硫酮-4,5-二氢[1,3]噻唑并[3,4-a]喹唑啉-8-羧酸甲酯）。STK1 抑制剂可作为抗生素耐药性的克星，抵御耐多药金黄色葡萄球菌。
• Methods and Compositions for Modulating Glycosylation
  申请人：Walker Kahne Suzanne

  公开号：US20090325944A1

  公开（公告）日：2009-12-31

  The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for treating glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins.
• METHODS AND COMPOSITIONS RELATED TO STK1-TARGETED SMALL MOLECULES AS ANTIBIOTIC RESISTANCE BREAKERS
  申请人：Ohio State Innovation Foundation

  公开号：US20200222416A1

  公开（公告）日：2020-07-16

  Disclosed are methods and compositions related to STK1 inhibitors, such as Inh2-B1 (methyl 5-oxo-3-(phenyl carbamoyl)-1-thioxo-4,5dihydro[1,3]thiazolo[3,4-a]quinazoline-8-carboxylate). The STK inhibitors can act as an antibiotic resistance breakers against multidrug-resistant Staphylococcus aureus.
• [EN] METHODS AND COMPOSITIONS FOR MODULATING GLYCOSYLATION<br/>[FR] PROCEDES ET COMPOSITIONS PERMETTANT DE MODULER LA GLYCOSYLATION
  申请人：HARVARD COLLEGE

  公开号：WO2007120638A2

  公开（公告）日：2007-10-25

  [EN] The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for treating glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins.
  [FR] L'invention porte sur des procédés et des produits permettant de moduler la glycosylation des protéines. L'invention est utile pour traiter des troubles associés à la glycosylation tels que la neurodégénérescence, le diabète et ses complications dont la résistance à l'insuline, la néphropathie, les dommages microvasculaires et le dysfonctionnement endothélial. L'invention porte également en partie sur des dosages qui sont utiles pour identifier et tester des composés candidats pour moduler la glycosylation de protéines.