tris{4-[2-(4-fluorophenyl)ethynyl]phenyl}amine | 848569-09-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tris{4-[2-(4-fluorophenyl)ethynyl]phenyl}amine
• 英文别名: 4-[2-(4-fluorophenyl)ethynyl]-N,N-bis[4-[2-(4-fluorophenyl)ethynyl]phenyl]aniline
• CAS: 848569-09-5
• 化学式: C₄₂H₂₄F₃N
• 分子量: 599.654
• InChiKey: WFGDCYUQGVRSOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.5
• 重原子数：
  46
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三(4-(2,2-二溴乙烯基)苯基)胺 、 (对氟苯基)3Bi 在 potassium phosphate 、 四(三苯基膦)钯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以69%的产率得到tris{4-[2-(4-fluorophenyl)ethynyl]phenyl}amine
  参考文献：
  名称：

  Pd-Catalyzed Domino Synthesis of Internal Alkynes Using Triarylbismuths as Multicoupling Organometallic Nucleophiles

  摘要：

  The domino coupling reaction of 1,1-dibromo-1-alkenes with triarylbismuth nucleophiles has been demonstrated to furnish disubstituted alkynes directly under catalytic palladium conditions. The couplings of triarylbismuths as multicoupling nucleophiles with 3 equiv of 1,1-dibromo-1alkenes are very fast, affording high yields of alkynes in a short reaction time. Thus, an efficient domino process has been accomplished using 1,1-dibromo-1-alkenes as surrogates for internal alkyne synthesis in couplings with triarylbismuths in a one-pot operation.

  DOI：

  10.1021/ol1004164

文献信息

• Pd-Catalyzed Domino Synthesis of Internal Alkynes Using Triarylbismuths as Multicoupling Organometallic Nucleophiles
  作者：Maddali L. N. Rao、Deepak N. Jadhav、Priyabrata Dasgupta

  DOI：10.1021/ol1004164

  日期：2010.5.7

  The domino coupling reaction of 1,1-dibromo-1-alkenes with triarylbismuth nucleophiles has been demonstrated to furnish disubstituted alkynes directly under catalytic palladium conditions. The couplings of triarylbismuths as multicoupling nucleophiles with 3 equiv of 1,1-dibromo-1alkenes are very fast, affording high yields of alkynes in a short reaction time. Thus, an efficient domino process has been accomplished using 1,1-dibromo-1-alkenes as surrogates for internal alkyne synthesis in couplings with triarylbismuths in a one-pot operation.