tert-Butyl-dimethyl-[1-phenyl-12-(tetrahydro-pyran-2-yloxy)-dodecyloxy]-silane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: tert-Butyl-dimethyl-[1-phenyl-12-(tetrahydro-pyran-2-yloxy)-dodecyloxy]-silane
• 英文别名: tert-butyl-dimethyl-[12-(oxan-2-yloxy)-1-phenyldodecoxy]silane
• 化学式: C₂₉H₅₂O₃Si
• 分子量: 476.816
• InChiKey: XRGJMSLUURRNFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.19
• 重原子数：
  33
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-Butyl-dimethyl-[1-phenyl-12-(tetrahydro-pyran-2-yloxy)-dodecyloxy]-silane 在 1,2-乙二硫醇 、 nickel dichloride 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 0.33h， 以65%的产率得到1-Phenyl-12-(tetrahydro-pyran-2-yloxy)-dodecan-1-ol
  参考文献：
  名称：

  A catalytic amount of nickel(II) chloride hexahydrate and 1,2-ethanedithiol is a good combination for the cleavage of tetrahydropyranyl (THP) and tert-butyldimethylsilyl (TBS) ethers

  摘要：

  Various THP and TBS ethers can be unmasked easily to the corresponding hydroxyl compounds in good yields by using a combination of a catalytic amount of nickel(II) chloride hexahydrate and 1,2-ethanedithiol at room temperature. In addition, alkyl TBS ethers can be hydrolyzed chemo selectively in the presence of aryl TBS ethers. Moreover, alkyl TBS ethers can be cleaved easily in the presence of alkyl or aryl THP ethers using the same conditions. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2004.11.011

文献信息

• A catalytic amount of nickel(II) chloride hexahydrate and 1,2-ethanedithiol is a good combination for the cleavage of tetrahydropyranyl (THP) and tert-butyldimethylsilyl (TBS) ethers
  作者：Abu T. Khan、Samimul Islam、Lokman H. Choudhury、Subrata Ghosh

  DOI：10.1016/j.tetlet.2004.11.011

  日期：2004.12

  Various THP and TBS ethers can be unmasked easily to the corresponding hydroxyl compounds in good yields by using a combination of a catalytic amount of nickel(II) chloride hexahydrate and 1,2-ethanedithiol at room temperature. In addition, alkyl TBS ethers can be hydrolyzed chemo selectively in the presence of aryl TBS ethers. Moreover, alkyl TBS ethers can be cleaved easily in the presence of alkyl or aryl THP ethers using the same conditions. (C) 2004 Published by Elsevier Ltd.