Methyl 11-benzyl-13-[methyl(3-piperidin-1-ylpropyl)amino]-3,8,10,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene-5-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Methyl 11-benzyl-13-[methyl(3-piperidin-1-ylpropyl)amino]-3,8,10,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene-5-carboxylate
• 英文别名: methyl 11-benzyl-13-[methyl(3-piperidin-1-ylpropyl)amino]-3,8,10,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene-5-carboxylate
• 化学式: C₂₇H₃₂N₆O₂
• 分子量: 472.6
• InChiKey: PJAHUMILXTXBHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  87.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS<br/>[FR] COMPOSÉS ET LEUR UTILISATION DANS L'EXPANSION DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES ET/OU CELLULES PROGÉNITRICES HÉMATOPOÏÉTIQUES
  申请人：UNIV MONTREAL

  公开号：WO2015161373A1

  公开（公告）日：2015-10-29

  Compounds of general formula or salts or prodrugs thereof, are provided and described herein. The compounds are useful to expand hematopoietic stem cell and/or hematopoietic progenitor cell populations. Particularly, the hematopoietic cells are human cells. The compounds are also useful in the medical treatment of hematopoietic disorder/malignancy, an autoimmune disease and/or an inherited immune-deficient disease in a subject.

  本文提供并描述了一般式化合物、盐或其前药。这些化合物对于扩增造血干细胞和/或造血祖细胞群体是有用的。特别地，这些造血细胞是人类细胞。这些化合物还可用于治疗受试者的造血障碍/恶性肿瘤、自身免疫疾病和/或遗传性免疫缺陷疾病。
• [EN] COMPOUNDS AND METHODS FOR ENHANCING VIRAL GENE TRANSFER TO HUMAN HEMATOPOIETIC CELLS<br/>[FR] COMPOSÉS ET PROCÉDÉ POUR L'ACCROISSEMENT DU TRANSFERT DE GÈNES VIRAUX VERS DES CELLULES HÉMATOPOÏÉTIQUES HUMAINES
  申请人：UNIV MONTREAL

  公开号：WO2016041080A1

  公开（公告）日：2016-03-24

  Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are based on the use of pyrimido[4,5- b]indole derivatives. Cell-based compositions and methods useful for therapeutic indications amenable to treatment with gene therapies, including hematopoietic stem cell therapies, are also described.

  描述了用于增强病毒基因转移（如慢病毒基因转移）并改善基因传递到原始造血细胞等细胞的方法和组合物。这些方法和组合物基于嘧啶并[4,5-b]吲哚衍生物的使用。还描述了用于治疗适合进行基因疗法治疗的治疗指标的细胞基础组合物和方法，包括造血干细胞疗法。
• Compounds and methods for enhancing viral gene transfer to human hematopoietic cells
  申请人：UNIVERSTÉ DE MONTRÉAL

  公开号：US10273503B2

  公开（公告）日：2019-04-30

  Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are based on the use of pyrimido[4,5-b]indole derivatives. Cell-based compositions and methods useful for therapeutic indications amenable to treatment with gene therapies, including hematopoietic stem cell therapies, are also described.

  本文介绍了增强病毒基因转移（如慢病毒基因转移）和提高向细胞（如原始造血细胞）传递基因的效力的方法和组合物。这些方法和组合物基于嘧啶并[4,5-b]吲哚衍生物的使用。此外，还介绍了适用于基因疗法（包括造血干细胞疗法）治疗适应症的细胞基组合物和方法。
• Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells
  申请人：UNIVERSITÉ DE MONTRÉAL

  公开号：US10647718B2

  公开（公告）日：2020-05-12

  Compounds of general formula or salts or prodrugs thereof, are provided and described herein. The compounds are useful to expand hematopoietic stem cell and/or hematopoietic progenitor cell populations. Particularly, the hematopoietic cells are human cells. The compounds are also useful in the medical treatment of hematopoietic disorder/malignancy, an autoimmune disease and/or an inherited immune-deficient disease in a subject.

  本文提供并描述了通式化合物或其盐类或原药。这些化合物可用于扩大造血干细胞和/或造血祖细胞群。特别是，造血细胞是人类细胞。这些化合物还可用于治疗受试者的造血障碍/恶性肿瘤、自身免疫性疾病和/或遗传性免疫缺陷疾病。
• COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS
  申请人：Université de Montréal

  公开号：EP3134409B1

  公开（公告）日：2020-02-12