2-[4-[4-(cyclopropanecarbonylamino)phenyl]phenyl]-1H-imidazo[4,5-b]pyridine-7-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-[4-(cyclopropanecarbonylamino)phenyl]phenyl]-1H-imidazo[4,5-b]pyridine-7-carboxylic acid
• 化学式: C₂₃H₁₈N₄O₃
• 分子量: 398.4
• InChiKey: SREYCORANSOANL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• TREATMENT OF TUMORS INCORPORATING MUTANT ISOCITRATE DEHYDROGENASE
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US20190025313A1

  公开（公告）日：2019-01-24

  The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with a DHODH inhibitor or an antimetabolite. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by a DHODH inhibitor or an antimetabolite, comprising assessing whether the tumor cell comprises a mutant IDH gene or protein whereby cells that comprise a mutant IDH gene or protein are sensitive to inhibition by DHODH inhibitors and antimetabolites.
• [EN] 3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS<br/>[FR] DÉRIVÉS DE 3H-IMIDAZO[4,5-B]PYRIDINE EN TANT QU'INHIBITEURS DE DIHYDROORORATE DÉSHYDROGÉNASE
  申请人：AURIGENE DISCOVERY TECH LTD

  公开号：WO2015166398A1

  公开（公告）日：2015-11-05

  The present invention provides 3H-imidazo[4,5-b]pyridine derivatives as dihydroorotate oxygenase inhibitor compounds of formula (I) wherein, R1, R2, R3 and 'n' have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, where there is an advantage in inhibiting DHODH. The present invention also provides methods for synthesizing 3H-imidazo[4,5-b]pyridine derivatives of formula (I). The present invention also provides pharmaceutical formulations comprising at least one of the DHODH inhibitory compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient.