5-methyl-2-(p-chlor-anilino)pyridine | 32635-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-methyl-2-(p-chlor-anilino)pyridine
• 英文别名: N-(4-chlorophenyl)-5-methylpyridin-2-amine；2-(4-Chlor-anilino)-5-methyl-pyridin
• CAS: 32635-60-2
• 化学式: C₁₂H₁₁ClN₂
• 分子量: 218.686
• InChiKey: KFBRAVXNFJWRQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-methyl-2-(p-chlor-anilino)pyridine 、 异氰酸苯酯 反应 3.0h， 以77%的产率得到1-(4-Chloro-phenyl)-1-(5-methyl-pyridin-2-yl)-3-phenyl-urea
  参考文献：
  名称：

  Hisano, Takuzo; Harano, Kazunobu; Matsuoka, Toshikazu, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 5, p. 1869 - 1877

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(4-氯苯)甲酰胺 在 三氟甲磺酸三甲基硅酯 、 三乙胺 、 三氯氧磷 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 14.25h， 生成 5-methyl-2-(p-chlor-anilino)pyridine 、 3-methyl-2-(p-chlor-anilino)pyridine
  参考文献：
  名称：

  2-Aminopyridines via Reaction of Pyridine N-Oxides and Activated Isocyanides

  摘要：

  A practical and efficient method for the synthesis of substituted 2-aminopyridines from pyridine N-oxides is reported. Yields of purified, isolated products of up to 84% are observed for the one-pot, two-step process. The reaction involves an in situ deprotection of an isolable N-formylaminopyridine intermediate and facilitates the synthesis of 2-aminopyridines for which other methods fail.

  DOI：

  10.1021/jo402693s

文献信息

• Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them
  申请人：BEECHAM GROUP PLC

  公开号：EP0000816A1

  公开（公告）日：1979-02-21

  A class of substituted amino pyridine derivatives are of value in the treatment of diabetes. Some of the compounds also possess hypolipidaemic activity. The compounds are represented by the formula (I): wherein R3 is hydrogen, alkyl or an acidic function; R2 is hydrogen or alkyl; R4 and R' are hydrogen, alkyl or halogen; Z is hydrogen, phenyl, alkyl or aralkyl; Alk is alkylene and x is 0 or 1; R1 is optionally substituted phenyl or naphthyl. Most of the compounds of formula (I) are novel.

  一类取代氨基吡啶衍生物具有治疗糖尿病的价值，其中一些化合物还具有降血脂活性。 这些化合物由式（I）表示：其中 R3 是氢、烷基或酸性官能团；R2 是氢或烷基；R4 和 R' 是氢、烷基或卤素；Z 是氢、苯基、烷基或芳烷基；Alk 是亚烷基，x 是 0 或 1；R1 是任选取代的苯基或萘基。 大多数式（I）化合物都是新型化合物。
• HISANO, TAKUZO;HARANO, KAZUNOBU;MATSUOKA, TOSHIKAZU;SUEMATSU, FUMIHIRO;OH+, CHEM. AND PHARM. BULL., 1985, 33, N 5, 1869-1877
  作者：HISANO, TAKUZO、HARANO, KAZUNOBU、MATSUOKA, TOSHIKAZU、SUEMATSU, FUMIHIRO、OH+

  DOI：——

  日期：——
• 2-Aminopyridines via Reaction of Pyridine <i>N</i>-Oxides and Activated Isocyanides
  作者：Mitchell Vamos、Nicholas D. P. Cosford

  DOI：10.1021/jo402693s

  日期：2014.3.7

  A practical and efficient method for the synthesis of substituted 2-aminopyridines from pyridine N-oxides is reported. Yields of purified, isolated products of up to 84% are observed for the one-pot, two-step process. The reaction involves an in situ deprotection of an isolable N-formylaminopyridine intermediate and facilitates the synthesis of 2-aminopyridines for which other methods fail.
• Hisano, Takuzo; Harano, Kazunobu; Matsuoka, Toshikazu, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 5, p. 1869 - 1877
  作者：Hisano, Takuzo、Harano, Kazunobu、Matsuoka, Toshikazu、Suematsu, Fumihiro、Ohizumi, Norihide

  DOI：——

  日期：——