2-methyl-3-ethylthiophene | 53119-51-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-methyl-3-ethylthiophene
• 英文别名: 2-Methyl-3-ethylthiophen；3-ethyl-2-methyl-thiophene；3-Aethyl-2-methyl-thiophen；Thiophene, 3-ethyl-2-methyl-；3-ethyl-2-methylthiophene
• CAS: 53119-51-0
• 化学式: C₇H₁₀S
• mdl: MFCD18451663
• 分子量: 126.222
• InChiKey: RBRAJDCWXUJHIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-methyl-3-ethylthiophene 在 三氯化铝 、 乙醇 、 Petroleum ether 作用下， 生成 1-(4-ethyl-5-methyl-[2]thienyl)-ethanone-(4-nitro-phenylhydrazone)
  参考文献：
  名称：

  Steinkopf et al., Justus Liebigs Annalen der Chemie, 1940, vol. 545, p. 45,49

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 tetraphosphorus trisulfide 作用下， 生成 2-methyl-3-ethylthiophene
  参考文献：
  名称：

  Steinkopf et al., Justus Liebigs Annalen der Chemie, 1940, vol. 545, p. 45,49

  摘要：

  DOI：

文献信息

• TRIARYLMETHANE COMPOUNDS AS REDOX INDICATORS IN THE SCHOENEMANN REACTION: II. SYNTHESES OF THE TRIARYLMETHANES
  作者：D. Morison Smith、R. Blanchfield、J. L. Thompson、G. A. Grant

  DOI：10.1139/v57-023

  日期：1957.2.1

  The syntheses and properties of a series of 4,4′-thenylidene bis[N,N-dimethylaniline] compounds, variously substituted in the thiophene ring, are reported. These compounds were tested as redox indicators in the Schoenemann reaction for the detection of phosphonofluoridate esters in solution. The most effective indicator was 4,4′(5-methyl-4-propyl-2-thenylidene)bis[N,N-dimethylaniline]

  报道了一系列在噻吩环中不同取代的4,4'-亚乙基双[N,N-二甲基苯胺]化合物的合成和性质。这些化合物被用作Schönenmann反应中检测溶液中磷酸氟酯酯的氧化还原指示剂。其中最有效的指示剂是4,4'(5-甲基-4-丙基-2-亚乙基)双[N,N-二甲基苯胺]。
• Active substance combination for the treatment of diabetes
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1946778A1

  公开（公告）日：2008-07-23

  The present invention relates to an active substance combination comprising at least one substituted pyrazoline compound and at least one drug, used to treat diabetes, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种活性物质组合，包括至少一种取代吡唑啉化合物和至少一种药物，用于治疗糖尿病，包括该活性物质组合的药物、包括该活性物质组合的制药配方以及利用该活性物质组合制造药物的用途。
• Substituted pyrazoline for preventing weight gain
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1946777A1

  公开（公告）日：2008-07-23

  The present invention relates to an active substance combination comprising at least one substituted pyrazoline compound and at least one drug, known to produce weight-gain as a side effect, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种活性物质组合，包括至少一种取代吡唑啉化合物和至少一种药物，该药物以体重增加作为副作用而知名，包括所述活性物质组合的药物、包括所述活性物质组合的药物制剂、以及利用所述活性物质组合制造药物。
• Heterocyclyl-substituted pyrazoline compounds, their preparation and use as medicaments
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1743894A1

  公开（公告）日：2007-01-17

  The present invention relates to heterocyclyl-substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

  本发明涉及杂环基取代的吡唑啉化合物、其制备方法、包含这些化合物的药物以及它们用于制备用于治疗人类和动物的药物的用途。
• Condensed isothiazolo-3 (2H)-one-1-1-dioxides
  申请人：Dr. Karl Thomae Gesellschaft mit beschrankter Haftung

  公开号：US04430355A1

  公开（公告）日：1984-02-07

  Compounds of the formula ##STR1## wherein X is oxygen or sulfur; R.sub.1 is hydrogen, methyl or ethyl; and R.sub.2 is methyl or ethyl; and non-toxic, physiologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as their salts are useful as sweetening agents.

  化合物的公式为##STR1##其中X是氧或硫; R.sub.1是氢，甲基或乙基; R.sub.2是甲基或乙基; 以及与无机或有机碱形成的非毒性，生理上可接受的盐。这些化合物以及它们的盐可用作甜味剂。