2-(2-bromo-3,4-dihydro-napthenen-1-yl)-3,6-dihydro-2H-pyran | 1071935-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(2-bromo-3,4-dihydro-napthenen-1-yl)-3,6-dihydro-2H-pyran
• 英文别名: 2-(2-bromo-3,4-dihydro-naphthalen-1-yl)-3,6-dihydro-2H-pyran；2-(2-bromo-3,4-dihydronaphthalen-1-yl)-3,6-dihydro-2H-pyran
• CAS: 1071935-88-0
• 化学式: C₁₅H₁₅BrO
• 分子量: 291.187
• InChiKey: SJEBVCQALGRGPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2-bromo-3,4-dihydro-napthenen-1-yl)-3,6-dihydro-2H-pyran 在 四丁基氯化铵 、 palladium diacetate 、 caesium carbonate 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.83h， 以82%的产率得到9,10-二氢菲
  参考文献：
  名称：

  Novel and Rapid Palladium-Assisted 6π Electrocyclic Reaction Affording 9,10-Dihydrophenanthrene and Its Analogues

  摘要：

  A novel methodology for the synthesis of 9,10-dihydrophenanthrene and its analogues has been developed via a palladium-assisted 6 pi electrocyclic reaction followed by formaldehyde elimination.

  DOI：

  10.1021/ol801882t
• 作为产物：
  描述：

  在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 以93%的产率得到2-(2-bromo-3,4-dihydro-napthenen-1-yl)-3,6-dihydro-2H-pyran
  参考文献：
  名称：

  Novel and Rapid Palladium-Assisted 6π Electrocyclic Reaction Affording 9,10-Dihydrophenanthrene and Its Analogues

  摘要：

  A novel methodology for the synthesis of 9,10-dihydrophenanthrene and its analogues has been developed via a palladium-assisted 6 pi electrocyclic reaction followed by formaldehyde elimination.

  DOI：

  10.1021/ol801882t

文献信息

• Novel and Rapid Palladium-Assisted 6π Electrocyclic Reaction Affording 9,10-Dihydrophenanthrene and Its Analogues
  作者：Rathin Jana、Indranil Chatterjee、Shubhankar Samanta、Jayanta K. Ray

  DOI：10.1021/ol801882t

  日期：2008.11.6

  A novel methodology for the synthesis of 9,10-dihydrophenanthrene and its analogues has been developed via a palladium-assisted 6 pi electrocyclic reaction followed by formaldehyde elimination.