Nicotinoylglykolsaeure | 1757-08-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Nicotinoylglykolsaeure
• 英文别名: [(3-Pyridinylcarbonyl)oxy]acetic acid；2-(pyridine-3-carbonyloxy)acetic acid
• CAS: 1757-08-0
• 化学式: C₈H₇NO₄
• mdl: MFCD01096627
• 分子量: 181.148
• InChiKey: SROFPEHSSYUWME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  76.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ESTERS OF O-SUBSTITUTED HYDROXY CARBOXYLIC ACIDS AND PREPARATIONS THEREOF
  申请人：Deng Liu

  公开号：US20120029198A1

  公开（公告）日：2012-02-02

  Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: wherein R and R 1 are independently selected from the group consisting of substituted and unsubstituted, branched- and straight-chain, saturated, unsaturated, and polyunsaturated C 1 -C 22 alkyl, substituted and unsubstituted C 3 -C 8 cycloalkyl, substituted and unsubstituted C 6 -C 20 carbocyclic aryl, and substituted and unsubstituted C 4 -C 20 heterocyclic; wherein the heteroatoms are selected from sulfur, nitrogen, and oxygen; and wherein n is 1-6. Process of producing esters of O-substituted hydroxy carboxylic acids are also provided.

  提供具有公式1、2或公式1和2的O-取代羟基羧酸酯，其中R和R1分别从以下组中独立选择：取代和未取代的支链和直链饱和、不饱和和多不饱和的C1-C22烷基，取代和未取代的C3-C8环烷基，取代和未取代的C6-C20碳环芳基，以及取代和未取代的C4-C20杂环；其中杂原子选自硫、氮和氧；n为1-6。还提供了生产O-取代羟基羧酸酯的方法。
• AROMATIC AND HETEROCYCLIC DERIVATIVES OF PHYTOSTEROLS AND/OR PHYTOSTANOLS FOR USE IN TREATING OR PREVENTING CARDIOVASCULAR DISEASE
  申请人：Forbes Medi-Tech Inc.

  公开号：EP1189923B1

  公开（公告）日：2004-12-29
• US8846723B2
  申请人：——

  公开号：US8846723B2

  公开（公告）日：2014-09-30
• US9532938B2
  申请人：——

  公开号：US9532938B2

  公开（公告）日：2017-01-03
• [EN] AROMATIC AND HETEROCYCLIC DERIVATIVES OF PHYTOSTEROLS AND/OR PHYTOSTANOLS FOR USE IN TREATING OR PREVENTING CARDIOVASCULAR DISEASE<br/>[FR] DERIVES AROMATIQUES ET HETEROCYCLIQUES DE PHYTOSTEROLS ET/OU DE PHYTOSTANOLS ET LEUR UTILISATION DANS LE TRAITEMENT OU LA PREVENTION DE L'AFFECTION CARDIO-VASCULAIRE
  申请人：FORBES MEDI TECH INC

  公开号：WO2000078789A1

  公开（公告）日：2000-12-28

  Novel phytosterol and/or phytostanol derivatives, including salts thereof, are represented by general formulae (I or II) wherein R is a phytosterol or phytostanol moiety; R2 is oxygen or hydrogen (H2) and R3 is an aromatic or heterocyclic unit. These derivatives are effective in treating and preventing cardiovascular disease and its underlying conditions including hyperlipidemia.