4-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(2-methoxyphenyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(2-methoxyphenyl)benzamide
• 英文别名: 4-(3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-(2-methoxyphenyl)benzamide
• 化学式: C₂₃H₂₀N₂O₄
• 分子量: 388.4
• InChiKey: DJNKPZHCFDLKGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  75.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• WNT PROTEIN SIGNALLING INHIBITORS
  申请人：Lum Lawrence

  公开号：US20110136813A1

  公开（公告）日：2011-06-09

  The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
• US8445491B2
  申请人：——

  公开号：US8445491B2

  公开（公告）日：2013-05-21
• US9045416B2
  申请人：——

  公开号：US9045416B2

  公开（公告）日：2015-06-02
• [EN] WNT PROTEIN SIGNALLING INHIBITORS<br/>[FR] INHIBITEURS DE SIGNALISATION DE LA PROTÉINE WNT
  申请人：UNIV TEXAS

  公开号：WO2009155001A2

  公开（公告）日：2009-12-23

  The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.