Thiophene-3-ol, 2,3-dihydro-, phenylcarbamate, 1,1-dioxide | 40226-77-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Thiophene-3-ol, 2,3-dihydro-, phenylcarbamate, 1,1-dioxide
• 英文别名: (1,1-dioxo-2,3-dihydrothiophen-3-yl) N-phenylcarbamate
• CAS: 40226-77-5
• 化学式: C₁₁H₁₁NO₄S
• 分子量: 253.28
• InChiKey: PSZHRXLWUMGYSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (1,1-dioxo-2,3-dihydrothiophen-3-yl) carbonochloridate 、 苯胺 以80%的产率得到
  参考文献：
  名称：

  PARXOMENKO P. I., UKR. XIM. ZH., 1980, 46, HO 12, 1294-1301

  摘要：

  DOI：

文献信息

• INHIBITORS OF ERK NUCLEAR TRANSLOCATION
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US20210292338A1

  公开（公告）日：2021-09-23

  Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R 1 and R′ 1 are aryl or heteroaryl as defined herein; and R 2 and R′ 2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.
• [EN] INHIBITORS OF ERK NUCLEAR TRANSLOCATION<br/>[FR] INHIBITEURS DE LA TRANSLOCATION NUCLÉAIRE D'ERK
  申请人：YEDA RES & DEV

  公开号：WO2020115744A1

  公开（公告）日：2020-06-11

  Described herein are compounds having Formula (I) or Formula (II): wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R'1 are aryl or heteroaryl as defined herein; and R 2 and R' 2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula (I) or Formula (II). The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.