7-羟基萘-2-羧酸乙酯 | 84701-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 7-羟基萘-2-羧酸乙酯
• 英文名称: 7-Hydroxy-2-naphthoesaeure-ethylester
• 英文别名: 7-hydroxynaphthalene-2-carboxylic acid ethyl ester；ethyl 7-hydroxynaphthalene-2-carboxylate
• CAS: 84701-39-3
• 化学式: C₁₃H₁₂O₃
• 分子量: 216.236
• InChiKey: PXWZTMTYCLZOCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-羟基萘-2-羧酸乙酯 在 lithium aluminium tetrahydride 、 sodium ethanolate 作用下， 以 四氢呋喃 、 乙醚 、 二甲基亚砜 为溶剂， 反应 20.5h， 生成 <(7-Hydroxymethyl)-2-naphthyl>-<<7-(hydroxymethyl)-2-naphthyl>methyl>ether
  参考文献：
  名称：

  Billen, Stephanie; Voegtle, Fritz, Chemische Berichte, 1989, vol. 122, p. 1113 - 1118

  摘要：

  DOI：
• 作为产物：
  描述：

  6-Benzoyloxy-naphthalene-2-carboxylic acid ethyl ester 以74%的产率得到
  参考文献：
  名称：

  KOPRANENKOV V. N.; MAKAROVA E. A.; LUKYANETS E. A., ZH. ORGAN. XIMII, 1981, 17, HO 2, 358-361

  摘要：

  DOI：

文献信息

• Ruthenium-Catalyzed Cross-Selective Asymmetric Oxidative Coupling of Arenols
  作者：Hiroki Hayashi、Takamasa Ueno、Chungsik Kim、Tatsuya Uchida

  DOI：10.1021/acs.orglett.0c00048

  日期：2020.2.21

  (Aqua)ruthenium(salen) complex 1c achieved good to high chemo- and enantioselective oxidative cross-coupling of arenols. The catalytic system can be used to selectively produce C1-symmetric bis(arenol)s from the combination of C3- and C7-substituted 2-naphthols or phenols even when there is no significant difference in oxidation potential between the cross-coupling partners. This unique cross-selectivity

  （水）钌（salen）配合物1c实现了良好的芳烃的化学-对映选择性氧化交叉偶联。该催化体系可用于从C3和C7取代的2-萘酚或苯酚的组合中选择性地生产C1对称的双（芳烯醇），即使在交叉偶联配偶体之间的氧化电位没有显着差异时。这种独特的交叉选择性受空间的影响而不是芳烃的电子作用，并且可以通过化学选择性单电子氧化和氧化碳-碳键形成来控制。
• Compounds
  申请人：Fisons Limited

  公开号：US04424231A1

  公开（公告）日：1984-01-03

  There are described compounds of formula I, ##STR1## in which Ra, Rb, Rc, Rd, Re, Rf and Rg, which may be the same or different, each represent hydrogen, amino, hydroxy, alkoxy, alkenyloxy, halogen, acyl, alkenyl, alkyl, or alkoxy substituted by phenyl, Rh is hydrogen, alkyl or --COOH. X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group, A has no significance or represents Y, OY, or SY and Y represents a C 1 to 4 hydrocarbon chain which is optionally substituted by alkyl C 1 to 4, E and G, which may be the same or different, each represent --O--, --S-- or --CH.sub.2 --, provided that at least one of E and G is --O-- or --S--, L, together with the carbon atoms to which it is attached, forms a benzene, furan, thiophene, pyrrole, or pyran-2-one ring, and pharmaceutically acceptable derivatives thereof.

  描述了具有以下化学式的化合物I，其中Ra、Rb、Rc、Rd、Re、Rf和Rg，可以相同也可以不同，每个代表氢、氨基、羟基、烷氧基、烯基氧基、卤素、酰基、烯基、烷基或被苯基取代的烷氧基，Rh代表氢、烷基或--COOH。X是一个含有2到10个碳原子的碳氢链，可以选择性地被一个羟基取代，A没有意义或代表Y、OY或SY，Y代表一个C1到4的碳氢链，可以选择性地被烷基C1到4取代，E和G，可以相同也可以不同，每个代表--O--、--S--或--CH2--，但至少其中之一是--O--或--S--，L与其连接的碳原子一起形成苯、呋喃、噻吩、吡咯或吡喃-2-酮环，并且其药用接受的衍生物。
• Naphthalene and 2-oxo-benzopyran acids and derivatives and
  申请人：Fisons plc

  公开号：US04518612A1

  公开（公告）日：1985-05-21

  There are described compounds of formula I, ##STR1## in which Ra, Rb, Rc, Rd, Re, Rf and Rg, which may be the same or different, each represent hydrogen, amino, hydroxy, alkoxy, alkenyloxy, halogen, acyl, alkenyl, alkyl, or alkoxy substituted by phenyl, Rh is hydrogen, alkyl or --COOH. X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group, A has no significance or represents Y, OY, or SY and Y represents a C 1 to 4 hydrocarbon chain which is optionally substituted by alkyl C 1 to 4, E and G, which may be the same or different, each represent --O--, --S-- or --CH.sub.2 --, provided that at least one of E and G is --O-- or --S--, L, together with the carbon atoms to which it is attached, forms a benzene, furan, thiophene, pyrrole, or pyran-2-one ring, and pharmaceutically acceptable derivatives thereof.

  公式I中描述了化合物，##STR1## 其中Ra、Rb、Rc、Rd、Re、Rf和Rg可以相同或不同，分别表示氢、氨基、羟基、烷氧基、烯基氧基、卤素、酰基、烯基、烷基或苯基取代的烷氧基，Rh表示氢、烷基或--COOH。X是一个含有2至10个碳原子的碳氢链，可以选择地被一个羟基取代，A没有意义或表示Y、OY或SY，Y表示一个C1至4的碳氢链，可以选择地被烷基C1至4取代，E和G可以相同或不同，分别表示--O--、--S--或--CH.sub.2--，但至少有一个是--O--或--S--，L与其附着的碳原子一起形成苯、呋喃、噻吩、吡咯或吡喃-2-酮环，并且其药学上可接受的衍生物。
• Methods of treating alzheimer's disease
  申请人：Nieman A. James

  公开号：US20060079533A1

  公开（公告）日：2006-04-13

  Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of 3,4-disubstituted piperidinyl compounds of formula (I) wherein the variables R 1 , R 2 , R 3 , R 4 , Q, W, X, Z, m, and n are defined herein.

  本发明公开了一种治疗阿尔茨海默病和其他疾病、抑制β-分泌酶酶和/或抑制哺乳动物中A beta肽沉积的方法，使用式(I)的3,4-二取代哌啶基化合物，其中变量R1、R2、R3、R4、Q、W、X、Z、m和n在此定义。
• Indium-Mediated Regio- and Chemoselective Synthesis of α-Hydroxyalkyl Allenic Esters and Gold-Catalyzed Cyclizations to Ethyl 2-Naphthoate Derivatives
  作者：Chansoo Park、Phil Ho Lee

  DOI：10.1021/ol801196g

  日期：2008.8.7

  The regio- and chemoselective synthetic method of functionalized alpha-hydroxyalkyl allenic esters was developed from the reactions of various aldehydes with organoindium reagent generated in situ from indium and ethyl 4-bromobutynoate. The alpha-hydroxyalkyl allenic esters possessing electron-donating groups were cyclized to ethyl 2-naphthoate derivatives through intramolecular C-alkylation catalyzed by gold salts.