2-Amino-2-phenyl-1,1-di(pyridin-3-yl)ethanol | 1228305-02-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Amino-2-phenyl-1,1-di(pyridin-3-yl)ethanol
• 英文别名: 2-amino-2-phenyl-1,1-dipyridin-3-ylethanol
• CAS: 1228305-02-9
• 化学式: C₁₈H₁₇N₃O
• 分子量: 291.352
• InChiKey: BBACDJSPZTWBIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  72
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-pyridyllithium 、 苯基甘氨酸甲酯 以 四氢呋喃 为溶剂， 生成 2-Amino-2-phenyl-1,1-di(pyridin-3-yl)ethanol
  参考文献：
  名称：

  Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

  摘要：

  A series of triarylethanolamine inhibitors of the Kv1.5 potassium channel have been prepared and evaluated for their effects in vitro and in vivo. The structure-activity relationship (SAR) studies described herein led to the development of potent, selective and orally active inhibitors of Kv1.5. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.005

文献信息

• Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel
  作者：Douglas C. Beshore、Nigel J. Liverton、Charles J. McIntyre、Christopher F. Claiborne、Brian Libby、J. Christopher Culberson、Joseph J. Salata、Christopher P. Regan、Joseph J. Lynch、Laszlo Kiss、Robert H. Spencer、Stephanie A. Kane、Rebecca B. White、Suzie Yeh、George D. Hartman、Christopher J. Dinsmore

  DOI：10.1016/j.bmcl.2010.03.005

  日期：2010.4

  A series of triarylethanolamine inhibitors of the Kv1.5 potassium channel have been prepared and evaluated for their effects in vitro and in vivo. The structure-activity relationship (SAR) studies described herein led to the development of potent, selective and orally active inhibitors of Kv1.5. (C) 2010 Elsevier Ltd. All rights reserved.