2-(methyl-[1]naphthylmethyl-amino)-ethanol | 151696-88-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(methyl-[1]naphthylmethyl-amino)-ethanol
• 英文别名: 2-(Methyl-[1]naphthylmethyl-amino)-aethanol；2-[Methyl(1-naphthylmethyl)amino]ethanol, AldrichCPR；2-[methyl(naphthalen-1-ylmethyl)amino]ethanol
• CAS: 151696-88-7
• 化学式: C₁₄H₁₇NO
• mdl: MFCD16152059
• 分子量: 215.295
• InChiKey: OSLTWBIEWFBEQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(methyl-[1]naphthylmethyl-amino)-ethanol 在 氯化亚砜 、 苯 作用下， 生成 (2-chloro-ethyl)-methyl-[1]naphthylmethyl-amine; hydrochloride
  参考文献：
  名称：

  US2573605

  摘要：

  公开号：
• 作为产物：
  描述：

  3-Methyl-2-naphthalen-1-yl-oxazolidine 在 氢化钾 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 2-(methyl-[1]naphthylmethyl-amino)-ethanol
  参考文献：
  名称：

  Reductive cleavage of N-substituted 2-aryl-1,3-oxazolidines: generation of .alpha.-amino-substituted carbanions

  摘要：

  The behavior of several N-substituted 2-aryl-1,3-oxazolidines has been investigated under conditions of electron transfer from alkali metals in aprotic solvents. The reduction led to the regioselective cleavage of the benzylic carbon-oxygen bond, with formation of the corresponding N-substituted benzylamino alcohols in good yields. Investigation of the mechanism of this reductive cleavage, with the aid of labeling experiments, showed the intermediate formation of alpha-tertiary amino-substituted carbanions.

  DOI：

  10.1021/jo00076a033

文献信息

• Multimodal Anion Exchange Matrices
  申请人：GE HEALTHCARE BIO-SCIENCES AB

  公开号：US20150299248A1

  公开（公告）日：2015-10-22

  The invention discloses a separation matrix which comprises a plurality of separation ligands, defined by the formula R 1 -L 1 -N(R 3 )-L 2 -R, immobilized on a support, wherein R 1 is a five- or six-membered, substituted or non-substituted ring structure or a hydroxyethyl or hydroxypropyl group; L 1 is either a methylene group or a covalent bond; R 2 is a five- or six-membered, substituted or non-substituted ring structure; L 2 is either a methylene group or a covalent bond; R 3 is a methyl group; and wherein if R 1 is a hydroxyethyl group and L 1 is a covalent bond, R 2 is a substituted aromatic ring structure or a substituted or non-substituted aliphatic ring structure.

  该发明揭示了一种分离基质，包括多个分离配体，其由公式R1-L1-N(R3)-L2-R所定义，固定在支撑物上，其中R1是一个五元或六元的取代或非取代环结构或一个羟乙基或羟丙基基团；L1是一个亚甲基基团或一个共价键；R2是一个五元或六元的取代或非取代环结构；L2是一个亚甲基基团或一个共价键；R3是一个甲基基团；如果R1是一个羟乙基基团且L1是一个共价键，则R2是一个取代芳香环结构或一个取代或非取代脂环结构。
• Programmable Amine Synthesis via Iterative Boron Homologation
  作者：Qiqiang Xie、Rui Zhang、Guangbin Dong

  DOI：10.1002/anie.202307118

  日期：2023.8.28

  Programmable amine synthesis is realized through sequential insertion of nitrogen and carbon atoms into boronate C−B bonds. This strategy is enabled by a new nitrenoid reagent, which allows for direct formation of aminoboranes from aryl or alkyl boronates via N-insertion.

  可编程胺合成是通过将氮和碳原子顺序插入硼酸CB键来实现的。这一策略是通过一种新的氮烯类试剂实现的，该试剂允许通过N-插入从芳基或烷基硼酸酯直接形成氨基硼烷。
• CINNAMIDE COMPOUND
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1757591A1

  公开（公告）日：2007-02-28

  The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) -C≡C- or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.

  本发明涉及一种由式（I）表示的化合物： (其中Ar1代表可被1至3个取代基取代的咪唑基；Ar2代表可被1至3个取代基取代的吡啶基、嘧啶基或苯基；X1代表(1)-C≡C-或(2)可被取代的双键等；R1和R2代表例如可被取代的C1-6烷基或C3-8环烷基）或其药理学上可接受的盐，以及其作为药剂的用途。
• Process for preparing phenyl-, pyridinyl- or pyrimidinyl-substituted imidazoles
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2261218A2

  公开（公告）日：2010-12-15

  The present invention relates to a process for preparing a compound of formula (6a): which comprises the step of: subjecting a compound of formula (5a): and a compound of formula (4a): to a coupling reaction,

  本发明涉及一种制备式（6a）化合物的工艺： 其中包括以下步骤 将式（5a）化合物 和式 (4a) 的化合物： 进行偶联反应、
• Multimodal anion exchange matrices
  申请人：GE Healthcare BioProcess R&D AB

  公开号：US10815269B2

  公开（公告）日：2020-10-27

  The invention discloses a separation matrix which comprises a plurality of separation ligands, defined by the formula R1-L1-N(R3)-L2-R, immobilized on a support, wherein R1 is a five- or six-membered, substituted or non-substituted ring structure or a hydroxyethyl or hydroxypropyl group; L1 is either a methylene group or a covalent bond; R2 is a five-or six-membered, substituted or non-substituted ring structure; L2 is either a methylene group or a covalent bond; R3 is a methyl group; and wherein if R1 is a hydroxyethyl group and L1 is a covalent bond, R2 is a substituted aromatic ring structure or a substituted or non-substituted aliphatic ring structure.

  本发明公开了一种分离基质，它包括固定在支持物上的由式 R1-L1-N(R3)-L2-R 定义的多个分离配体，其中 R1 是五元或六元、取代或非取代的环结构或羟乙基或羟丙基；L1 是亚甲基或共价键；R2 是五元或六元、取代或非取代的环结构；L2 是亚甲基或共价键；R3 是甲基；如果 R1 是羟乙基，L1 是共价键，则 R2 是取代的芳环结构或取代或非取代的脂环结构。