8-Methyl-1,3-diphenyl-5-phenylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione | 177082-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 8-Methyl-1,3-diphenyl-5-phenylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione
• 英文别名: 5-Anilino-8-methyl-1,3-diphenyl-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-2,4,7-trione；5-anilino-8-methyl-1,3-diphenylpyrido[2,3-d]pyrimidine-2,4,7-trione
• CAS: 177082-62-1
• 化学式: C₂₆H₂₀N₄O₃
• 分子量: 436.47
• InChiKey: UWHPGBMOMNSDQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  73
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N-二甲基甲酰胺 、 8-Methyl-1,3-diphenyl-5-phenylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione 在 sodium hydroxide 、 三氯氧磷 作用下， 生成 5-甲基-2,4-二苯基苯并[b]嘧啶并[4,5-h][1,6]二氮杂萘-1,3,6(2H,4H,5H)-三酮
  参考文献：
  名称：

  Ring closure reaction of 5-hydroxy-pyrido[2,3-d]pyrimidine-2,4,7-triones to benzo[b]pyrimido[4,5-h]1,6-naphthyridine-1,3,6-triones

  摘要：

  N-Substituted aminouracils (1) react with malonates by cyclocondensation to 5-hydroxy-pyrido [2,3-d] pyrimidine-2,4,7-triones (2), which give with triethylorthoformate and aniline 6-(phenylaminomethylene)-pyrido[2,3-d]pyrimidine-tetraone (3). Halogenation of 2a-d (with R(2) = Me) with phosphorylchloride leads to 5,7-dichloro-pyrido [2,3-d]pyrimidine-2,4-diones (4) by cleavage of the methyl group at N-8, whereas Vilsmeier reaction of 2 affords 5-chloro-6-formyl derivatives (6), which cyclize with arylamines to give benzo[b]pyrimido[4,5-h] 1,6-naphthyridines (9). Compounds 9 were obtained independently by amination of the tosylates 5 to the 5-arylamino compounds 8, and Vilsmeier formylation to yield 9.

  DOI：

  10.1002/prac.19963380129
• 作为产物：
  描述：

  6-methylamino-1,3-diphenyl-1H-pyrimidine-2,4-dione 在 三乙胺 作用下， 以 二苯醚 、 异丙醇 、 乙腈 为溶剂， 反应 14.0h， 生成 8-Methyl-1,3-diphenyl-5-phenylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione
  参考文献：
  名称：

  Ring closure reaction of 5-hydroxy-pyrido[2,3-d]pyrimidine-2,4,7-triones to benzo[b]pyrimido[4,5-h]1,6-naphthyridine-1,3,6-triones

  摘要：

  N-Substituted aminouracils (1) react with malonates by cyclocondensation to 5-hydroxy-pyrido [2,3-d] pyrimidine-2,4,7-triones (2), which give with triethylorthoformate and aniline 6-(phenylaminomethylene)-pyrido[2,3-d]pyrimidine-tetraone (3). Halogenation of 2a-d (with R(2) = Me) with phosphorylchloride leads to 5,7-dichloro-pyrido [2,3-d]pyrimidine-2,4-diones (4) by cleavage of the methyl group at N-8, whereas Vilsmeier reaction of 2 affords 5-chloro-6-formyl derivatives (6), which cyclize with arylamines to give benzo[b]pyrimido[4,5-h] 1,6-naphthyridines (9). Compounds 9 were obtained independently by amination of the tosylates 5 to the 5-arylamino compounds 8, and Vilsmeier formylation to yield 9.

  DOI：

  10.1002/prac.19963380129

文献信息

• PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF
  申请人：Kawasaki Hisashi

  公开号：US20080312228A1

  公开（公告）日：2008-12-18

  The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

  本发明涉及一种嘧啶化合物或其药学上可接受的盐，其由以下公式[I]所表示，其中每个符号如规范中所定义，并提供了一种治疗或预防不良细胞增殖的方法，包括给予这种化合物。本发明的化合物在抑制不良细胞增殖，特别是抗肿瘤活性方面具有优越性，并且可用作抗肿瘤剂，用于预防或治疗癌症、风湿病等。此外，本发明的化合物在与其他抗肿瘤剂如烷基化剂或代谢拮抗剂联合使用时，可成为更有效的抗肿瘤剂。
• PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF
  申请人：Japan Tobacco Inc.

  公开号：US20150183812A1

  公开（公告）日：2015-07-02

  The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

  本发明涉及一种由以下式[I]所表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如规范中所定义，以及治疗或预防不良细胞增殖的方法，包括给予这样的化合物。本发明的化合物在抑制不良细胞增殖，特别是抗肿瘤活性方面具有优越性，并且在预防或治疗癌症、风湿病等方面作为抗肿瘤剂非常有用。此外，本发明的化合物在与其他抗肿瘤剂如烷基化剂或代谢拮抗剂联合使用时，可以更有效地作为抗肿瘤剂。
• US7378423B2
  申请人：——

  公开号：US7378423B2

  公开（公告）日：2008-05-27
• US8835443B2
  申请人：——

  公开号：US8835443B2

  公开（公告）日：2014-09-16
• Ring closure reaction of 5-hydroxy-pyrido[2,3-d]pyrimidine-2,4,7-triones to benzo[b]pyrimido[4,5-h]1,6-naphthyridine-1,3,6-triones
  作者：Ahmed F. A. Khattab、Dang Van Tinh、Wolfgang Stadlbauer

  DOI：10.1002/prac.19963380129

  日期：——

  N-Substituted aminouracils (1) react with malonates by cyclocondensation to 5-hydroxy-pyrido [2,3-d] pyrimidine-2,4,7-triones (2), which give with triethylorthoformate and aniline 6-(phenylaminomethylene)-pyrido[2,3-d]pyrimidine-tetraone (3). Halogenation of 2a-d (with R(2) = Me) with phosphorylchloride leads to 5,7-dichloro-pyrido [2,3-d]pyrimidine-2,4-diones (4) by cleavage of the methyl group at N-8, whereas Vilsmeier reaction of 2 affords 5-chloro-6-formyl derivatives (6), which cyclize with arylamines to give benzo[b]pyrimido[4,5-h] 1,6-naphthyridines (9). Compounds 9 were obtained independently by amination of the tosylates 5 to the 5-arylamino compounds 8, and Vilsmeier formylation to yield 9.