Methyl 5-chloro-3-nitropicolinate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Methyl 5-chloro-3-nitropicolinate
• 英文别名: methyl 5-chloro-3-nitropyridine-2-carboxylate
• 化学式: C7H5ClN2O4
• 分子量: 216.58
• InChiKey: LDIMWIHRCQNRAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• HETEROARYL SULFONAMIDES AND CCR2/CCR9
  申请人：ChemoCentryx, Inc.

  公开号：US20170095458A1

  公开（公告）日：2017-04-06

  Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.