1-(2,4-Dibromopyridin-3-yl)ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(2,4-Dibromopyridin-3-yl)ethanone
• 英文别名: 1-(2,4-dibromopyridin-3-yl)ethanone
• 化学式: C₇H₅Br₂NO
• 分子量: 278.93
• InChiKey: AFIMVMYLWUBMJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PROCESS FOR PRODUCING OPTICALLY ACTIVE SECONDARY ALCOHOL
  申请人：KANTO KAGAKU KABUSHIKI KAISHA

  公开号：US20150031920A1

  公开（公告）日：2015-01-29

  [Object] The object of this invention is to provide a method for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound. [Solution] The method of producing an optically active secondary alcohol according to the present invention is characterized in that a substrate carbonyl compound (provided that 3-quinuclidinone, 3-quinuclidinone derivative having a substituent, and a ketone having an aromatic hydrocarbon group and a heterocycle are excluded) is reacted with hydrogen and/or a hydrogen donating compound in the presence of a ruthenium complex selected from the compounds expressed by following general formula (1) RuXYAB (1) [in the general formula (1), X and Y are the same or different from each other and denote a hydrogen atom or an anionic group, A denotes an optically active diphosphine expressed by the general formula (2), B denotes an amine compound expressed by following general formula (3)].

  本发明的目的是提供一种通过在高效率下使用一种作为催化剂的钌配合物，其中该钌配合物携带某种光学活性的二膦化合物和一种易于合成的胺化合物，从而在高光学纯度下加氢化底物羰基化合物生产光学活性二级醇的方法。 根据本发明的一种生产光学活性二级醇的方法的特征在于，在一种选择自下述通用式（1）RuXYAB所表示的化合物的钌配合物的存在下，将底物羰基化合物（假设排除3-喹啉酮、带有取代基的3-喹啉酮衍生物以及具有芳香烃基和杂环的酮）与氢气和/或氢供体化合物反应。[在通用式（1）中，X和Y相同或不同，表示氢原子或阴离子基团，A表示由通用式（2）表示的光学活性二膦，B表示由下述通用式（3）表示的胺化合物]。
• Process for producing optically active secondary alcohol
  申请人：Kanto Kagaku Kabushiki Kaisha

  公开号：EP2865446A1

  公开（公告）日：2015-04-29

  The object of this invention is to provide a method for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound. The method of producing an optically active secondary alcohol according to the present invention is characterized in that a substrate carbonyl compound (provided that 3-quinuclidinone, 3-quinuclidinone derivative having a substituent, and a ketone having an aromatic hydrocarbon group and a heterocycle are excluded) is reacted with hydrogen and/or a hydrogen donating compound in the presence of a ruthenium complex selected from the compounds expressed by following general formula (1) RuXYAB (1) [in the general formula (1), X and Y are the same or different from each other and denote a hydrogen atom or an anionic group, A denotes an optically active diphosphine expressed by the general formula (2), B denotes an amine compound expressed by following general formula (3)].

  本发明的目的是提供一种高光学纯度的光学活性仲醇的制取方法，该方法是以某种光学活性二膦化合物和易于合成的胺化合物为配体的钌络合物为催化剂，通过高效率地氢化底物羰基化合物来制取光学活性仲醇。 根据本发明的生产光学活性仲醇的方法，其特征在于底物羰基化合物(但不包括3-奎宁环酮、具有取代基的3-奎宁环酮衍生物和具有芳香烃基和杂环的酮)在选自通式(1)RuXYAB(1)的化合物的钌络合物存在下与氢和/或氢捐赠化合物反应[在通式(1)中、X 和 Y 彼此相同或不同，表示氢原子或阴离子基团，A 表示通式 (2) 所表示的光学活性二膦，B 表示通式 (3) 所表示的胺化合物]。
• US9174906B2
  申请人：——

  公开号：US9174906B2

  公开（公告）日：2015-11-03