3-(2-Ethoxy-5-methoxyphenyl)-1-(5-methoxypyridin-2-yl)sulfonyl-3-[6-(1-methylpiperidin-4-yl)-2,6-diazaspiro[3.3]heptan-2-yl]-2-oxoindole-5-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(2-Ethoxy-5-methoxyphenyl)-1-(5-methoxypyridin-2-yl)sulfonyl-3-[6-(1-methylpiperidin-4-yl)-2,6-diazaspiro[3.3]heptan-2-yl]-2-oxoindole-5-carbonitrile
• 英文别名: 3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxypyridin-2-yl)sulfonyl-3-[6-(1-methylpiperidin-4-yl)-2,6-diazaspiro[3.3]heptan-2-yl]-2-oxoindole-5-carbonitrile
• 化学式: C₃₅H₄₀N₆O₆S
• 分子量: 672.8
• InChiKey: MVTJRSQNHIRFRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  48
• 可旋转键数：
  9
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  137
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• [EN] OXINDOLE COMPOUNDS CARRYING A NITROGEN-BOUND SPIRO SUBSTITUENT AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES<br/>[FR] COMPOSÉS D'OXINDOLE PORTANT UN SUBSTITUANT SPIRO LIÉ À UN ATOME D'AZOTE, ET LEUR UTILISATION POUR LE TRAITEMENT DE MALADIES LIÉES À LA VASOPRESSINE
  申请人：ABBVIE DEUTSCHLAND

  公开号：WO2015173393A1

  公开（公告）日：2015-11-19

  The present invention relates to novel substituted oxindole derivatives of the formula I wherein A is a ring selected from phenyl and 6-membered hetaryl containing 1 or 2 nitrogen atoms as ring members, where ring A carries one substituent R6 and optionally one substituent R7;B is a ring selected from phenyland a monocyclic or bicyclic het- eroaromatic ring containing 1, 2 or 3 heteroatoms selected from O, N and S as ring members, where ring B may carry 1, 2 or 3 substituents R8;X1, X2, X3 and X4, independently of each other, are selected from -CH2-, -O-, -S(O)c-, -NH-, -C(O)-, -CH2CH2-,-CH2O-, -OCH2-, -S(O)cCH2-, -CH2S(O)c-, CH2NH-,-NHCH2-, -CH2C(O)-andC(O)CH2-;X5 is NH,CH2or O,;and wherein c, R1, R2, (R3)a, (R4)b, R5, R6, R7, and R8 are as defined in the claims. The present invention also relates to pharmaceutical compositions comprising the novel substituted oxindole derivatives of the formula I, and to their use for the treatment of vasopressin-related disorders.

  本发明涉及一种新型的氧吲哚衍生物，其化学式为I，其中A是从苯基和含有1或2个氮原子作为环成员的6元杂环中选择的环，其中环A携带一个取代基R6和可选的一个取代基R7；B是从苯基和含有1、2或3个氧、氮和硫原子作为环成员的单环或双环杂芳环中选择的环，其中环B可能携带1、2或3个取代基R8；X1、X2、X3和X4，彼此独立地从-CH2-、-O-、-S(O)c-、-NH-、-C(O)-、-CH2CH2-、-CH2O-、-OCH2-、-S(O)cCH2-、-CH2S(O)c-、CH2NH-、-NHCH2-、-CH2C(O)-和C(O)CH2-中选择；X5是NH、CH2或O；其中c、R1、R2、(R3)a、(R4)b、R5、R6、R7和R8如权利要求中所定义。本发明还涉及包含化学式I中的新型氧吲哚衍生物的药物组合物，以及它们用于治疗与加压素相关的疾病。
• OXINDOLE COMPOUNDS CARRYING A NITROGEN-BOUND SPIRO SUBSTITUENT AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：US20150329551A1

  公开（公告）日：2015-11-19

  The present invention relates to novel substituted oxindole derivatives of the formula I wherein A is a ring selected from phenyl and 6-membered hetaryl containing 1 or 2 nitrogen atoms as ring members, where ring A carries one substituent R 6 and optionally one substituent R 7 ; B is a ring selected from phenyl and a monocyclic or bicyclic heteroaromatic ring containing 1, 2 or 3 heteroatoms selected from O, N and S as ring members, where ring B may carry 1, 2 or 3 substituents R 8 ; X 1 , X 2 , X 3 and X 4 , independently of each other, are selected from —CH 2 —, —O—, —S(O) c —, —NH—, —C(O)—, —CH 2 CH 2 —, —CH 2 O—, —OCH 2 —, —S(O) c CH 2 —, —CH 2 S(O) c —, CH 2 NH—, —NHCH 2 —, —CH 2 C(O)— and C(O)CH 2 —; X 5 is NH, CH 2 or O; and wherein c, R 1 , R 2 , (R 3 ) a , (R 4 ) b , R 5 , R 6 , R 7 , and R 8 are as defined in the claims. The present invention also relates to pharmaceutical compositions comprising the novel substituted oxindole derivatives of the formula I, and to their use for the treatment of vasopressin-related disorders

  本发明涉及公式I的新型取代的氧化吲哚衍生物，其中A是从苯和6元杂环中选择的环，该6元杂环含有1或2个氮原子作为环成员，环A携带一个取代基R6和可选的一个取代基R7；B是从苯和含有1、2或3个杂原子（O、N和S）作为环成员的单环或双环杂芳环中选择的环，环B可能携带1、2或3个取代基R8；X1、X2、X3和X4，彼此独立地，选择自—CH2—、—O—、—S(O)c—、—NH—、—C(O)—、—CH2CH2—、—CH2O—、—OCH2—、—S(O)cCH2—、—CH2S(O)c—、CH2NH—、—NHCH2—、—CH2C(O)—和C(O)CH2—；X5为NH、CH2或O；其中c、R1、R2、（R3）a、（R4）b、R5、R6、R7和R8如权利要求所定义。 本发明还涉及包含公式I的新型取代的氧化吲哚衍生物的药物组合物，以及它们用于治疗与加压素相关的疾病的用途。
• US9688678B2
  申请人：——

  公开号：US9688678B2

  公开（公告）日：2017-06-27