4-[[4-[[4-[[4-Amino-3-methoxy-2-[[4-[(4-nitrobenzoyl)amino]benzoyl]amino]-4-oxobutanoyl]amino]benzoyl]amino]-2-hydroxy-3-propan-2-yloxybenzoyl]amino]-2-hydroxy-3-propan-2-yloxybenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[[4-[[4-[[4-Amino-3-methoxy-2-[[4-[(4-nitrobenzoyl)amino]benzoyl]amino]-4-oxobutanoyl]amino]benzoyl]amino]-2-hydroxy-3-propan-2-yloxybenzoyl]amino]-2-hydroxy-3-propan-2-yloxybenzoic acid
• 英文别名: 4-[[4-[[4-[[4-amino-3-methoxy-2-[[4-[(4-nitrobenzoyl)amino]benzoyl]amino]-4-oxobutanoyl]amino]benzoyl]amino]-2-hydroxy-3-propan-2-yloxybenzoyl]amino]-2-hydroxy-3-propan-2-yloxybenzoic acid
• 化学式: C46H45N7O15
• 分子量: 935.9
• InChiKey: QUGQHCSHBGAXCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  68
• 可旋转键数：
  18
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  340
• 氢给体数：
  9
• 氢受体数：
  15

文献信息

• [EN] NOVEL CYSTOBACTAMIDES<br/>[FR] NOUVEAUX CYSTOBACTAMIDES
  申请人：HELMHOLTZ ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH

  公开号：WO2016082934A1

  公开（公告）日：2016-06-02

  The present invention provides cystobactamides of formula (I) and the use thereof the treatment or prophylaxis of bacterial infections.

  本发明提供了式(I)的囊胞菌素及其在治疗或预防细菌感染中的用途。
• Cystobactamides
  申请人：HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH

  公开号：US10519099B2

  公开（公告）日：2019-12-31

  The present invention provides a method for the treatment or prophylaxis of bacterial infections by administering to a subject in need thereof an effective amount of a compound of formula.

  本发明提供了一种治疗或预防细菌感染的方法，给有需要的受试者施用有效量的式化合物。
• NOVEL ANTIMICROBIAL COMPOUND AND USE THEREOF
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：US20170204052A1

  公开（公告）日：2017-07-20

  The present invention relates to: coralmycin A and B, which are novel compounds exhibiting antimicrobial activity, an isomer thereof, a derivative thereof or a pharmaceutically acceptable salt thereof; a microorganism of the genus Corallococcus producing the same; and an antimicrobial use thereof. The coralmycin A and B have very strong antimicrobial activity against antibiotic-resistant bacteria such as MRSA, QRSA, VRE, VISA, etc.; Acinetobacter baumannii, which is a multidrug-resistant microorganism; and also against gram-positive microorganisms and gram-negative microorganisms. Therefore, the present invention can be very useful for prevention, treatment and alleviation of various microbial infections, and thus can be widely applied to the medical supply, quasi-drug, food, and feed industries.
• NOVEL CYSTOBACTAMIDES
  申请人：HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH

  公开号：US20170327458A1

  公开（公告）日：2017-11-16

  The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.