N-methyl-2-pyridin-1-ium-1-ylacetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-methyl-2-pyridin-1-ium-1-ylacetamide
• 化学式: C8H11N2O+
• 分子量: 151.19
• InChiKey: MMTBTGPRUICPTO-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  33
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Novel cyclic compound having 4-pyridylalkylthio group having substituted or unsubstituted amino group introduced therein
  申请人：Honda Takahiro

  公开号：US20070149574A1

  公开（公告）日：2007-06-28

  A novel cyclic compound having a 4-pyridylalkylthio group having an (un)substituted amino group introduced therein or a salt thereof. They are useful as a medicine. The cyclic compound is a compound represented by the following formula (1), which is useful for the treatment of diseases in which angiogenesis participates. In the following formula (1), ring A represents a benzene ring or a 5- or 6-membered aromatic heterocycle optionally fused with a cycloalkane ring; B represents alkylene; R 1 and R 2 each represents H, (substituted) aryl, (substituted) heterocyclic group, etc.; R 3 and R 4 each represents H, (substituted) alkyl, (substituted) cycloalkyl, -Z-R 5 , etc.; R 5 represents (substituted) alkyl, (substituted) aryl, (substituted) heterocyclic group, etc.; X and Y each represents H, etc.; Z represents —CO—, —COO—, —CONR 6 —, —SO 2 —, etc.; R 6 represents H, etc.; p is 0, 1, or 2; and q is 0 or 1.

  一种具有4-吡啶基烷基硫基团的新型环状化合物，其中引入了（未）取代氨基或其盐。它们可用作药物。环状化合物是由以下式（1）表示的化合物，可用于治疗参与血管生成的疾病。在下式（1）中，环A表示苯环或5-或6-成员芳香杂环，可选择地与环烷环融合；B表示烷基；R1和R2各表示H，（取代）芳基，（取代）杂环基等；R3和R4各表示H，（取代）烷基，（取代）环烷基，-Z-R5等；R5表示（取代）烷基，（取代）芳基，（取代）杂环基等；X和Y各表示H等；Z表示-CO-，-COO-，-CONR6-，-SO2-等；R6表示H等；p为0、1或2；q为0或1。
• Process for producing dioxazine compounds, colored materials therewith and dioxazine compounds having a plate-like crystal form
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP0685530A1

  公开（公告）日：1995-12-06

  The present invention relates to a process for producing a dioxazine compound represented by the formula (1) which comprises carrying out a ring closure reaction of a compound represented by the formula (2) in the presence of a dioxazine derivative of the formula (3), colored materials containing this dioxazine compound, and dioxazine compounds having a plate-like crystal form:    The pigment crude obtained according to the process of this invention can be worked into a pigment very easily as compared with those produced according to the conventional methods, and the pigment obtained therefrom has excellent fastness properties, fluidity, gloss and coloring power.

  本发明涉及一种生产式（1）表示的二噁嗪化合物的工艺，该工艺包括在式（3）的二噁嗪衍生物、含有该二噁嗪化合物的有色材料和具有板状晶体的二噁嗪化合物的存在下，对式（2）表示的化合物进行闭环反应： 与按照传统方法生产的颜料相比，按照本发明的工艺获得的颜料粗料非常容易加工成颜料，而且由此获得的颜料具有优异的牢度、流动性、光泽度和着色力。
• Ceramides and Apoptosis-Signaling Ligand
  申请人：Bielawska Alicja

  公开号：US20080045470A1

  公开（公告）日：2008-02-21

  The invention provides the compounds of formula ( ): and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
  申请人：Ramirez De Molina Ana

  公开号：US20110256241A1

  公开（公告）日：2011-10-20

  The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and a chemotherapeutic agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and a death receptor ligand and uses thereof for the treatment of cancer.
• KIT AND METHOD FOR QUANTITATIVE DETECTION OF STEROIDS
  申请人：SWANSEA UNIVERSITY

  公开号：US20150233953A1

  公开（公告）日：2015-08-20

  The invention relates to a kit and methods for quantitative detection of steroids in a sample. The kit comprises quantitative charge tags and an oxidising agent.