7,8-Dimethoxy-5-(2-methoxyphenyl)pyrrolo[3,4-c]isoquinoline-1,3-dione | 1022782-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 7,8-Dimethoxy-5-(2-methoxyphenyl)pyrrolo[3,4-c]isoquinoline-1,3-dione
• CAS: 1022782-05-3
• 化学式: C₂₀H₁₆N₂O₅
• 分子量: 364.357
• InChiKey: FSFNSMIHZMVOAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  86.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  邻甲氧基苯甲醛 、 3-amino-4-(3,4-dimethoxyphenyl)maleimide 在 三氟乙酸 作用下， 以64%的产率得到7,8-Dimethoxy-5-(2-methoxyphenyl)pyrrolo[3,4-c]isoquinoline-1,3-dione
  参考文献：
  名称：

  Acid cyclization of amino-substituted heterocycles. Synthesis of 1,3-dioxo- pyrrolo[3,4-c]- and thieno[3,4-c]isoquino- lines and cinnolines

  摘要：

  The reaction of 3-amino-4-(3,4-dimethoxyphenyl)maleimide and the methyl esters of 3-amino-4-(3,4-dimethoxyphenyl)-5-R-thiophene-2-carboxylic acids with carbonyl compounds and nitrous acid has been investigated. Dioxopyrrolo[3,4-c]- and thieno[3,4-c]isoquinolines and cinnolines were obtained.

  DOI：

  10.1007/s10593-009-0262-2

文献信息

• Acid cyclization of amino-substituted heterocycles. Synthesis of 1,3-dioxo- pyrrolo[3,4-c]- and thieno[3,4-c]isoquino- lines and cinnolines
  作者：S. Yu. Zinchenko、R. A. Efimenko、S. Yu. Suikov、K. I. Kobrakov、S. L. Bogza

  DOI：10.1007/s10593-009-0262-2

  日期：2009.3

  The reaction of 3-amino-4-(3,4-dimethoxyphenyl)maleimide and the methyl esters of 3-amino-4-(3,4-dimethoxyphenyl)-5-R-thiophene-2-carboxylic acids with carbonyl compounds and nitrous acid has been investigated. Dioxopyrrolo[3,4-c]- and thieno[3,4-c]isoquinolines and cinnolines were obtained.